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Treatment of Patients with Multiple Sclerosis Transitioning Between Relapsing and Progressive Disease

期刊: CNS DRUGS, 2023; 37 (1)

Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative disease of the central nervous system with a wide variety of clini......

Pharmacological Management of Borderline Personality Disorder and Common Comorbidities

期刊: CNS DRUGS, 2023; 37 (6)

Comorbidity between borderline personality disorder (BPD) and other mental disorders is common. Although no specific pharmacological treatments have b......

Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders

期刊: CNS DRUGS, 2023; 37 (5)

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein wi......

Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review

期刊: CNS DRUGS, 2023; 37 (6)

IntroductionPhantom limb pain (PLP) refers to pain perceived in a part of the body removed by amputation or trauma. Despite the high prevalence of PLP......

Efgartigimod Alfa in Generalised Myasthenia Gravis: A Profile of Its Use

期刊: CNS DRUGS, 2023; 37 (5)

Intravenous efgartigimod alfa (also known as efgartigimod alfa-fcab in the USA; Vyvgart (R)) is the first neonatal Fc receptor antagonist approved in ......

Treatment Outcomes of Newly Diagnosed Epilepsy: A Systematic Review and Meta-analysis

期刊: CNS DRUGS, 2023; 37 (1)

Background and Objectives Understanding the multi-faceted treatment outcomes of newly diagnosed epilepsy is critical for developing rational therapeut......

Rimegepant: A Review in the Acute Treatment and Preventive Treatment of Migraine

期刊: CNS DRUGS, 2023; 37 (3)

Rimegepant [Nurtec((R)) ODT (USA); Vydura((R)) (EU)] is a calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment ......

BRAF Mutations in CNS Tumors-Prognostic Markers and Therapeutic Targets

期刊: CNS DRUGS, 2023; 37 (7)

Gliomas are a heterogeneous group of brain tumors with limited therapeutic options. However, identification of BRAF V600E mutations in a subset of gli......

Effectiveness and Safety of Switching from Oral Antipsychotics to Once-Monthly Paliperidone Palmitate (PP1M) in the Management of Schizophrenia: A Systematic Review and Meta-Analysis

期刊: CNS DRUGS, 2023; 37 (8)

BackgroundConsidering the improvement in adherence and convenience, once-monthly paliperidone palmitate (PP1M) has been increasingly used in the treat......

Levetiracetam Interaction with Direct Oral Anticoagulants: A Pharmacovigilance Study

期刊: CNS DRUGS, 2023; 37 (12)

Background Levetiracetam is widely used in post-stroke epilepsy. However, it is suspected to possess P-glycoprotein (P-gp) induction properties, and t......

Switching OnabotulinumtoxinA to Monoclonal Anti-CGRP Antibodies in Drug-Resistant Chronic Migraine

期刊: CNS DRUGS, 2023; 37 (2)

BackgroundOnabotulinumtoxinA (BTX-A) and anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (anti-CGRP mAbs) are approved drugs for chr......

Stopping Disease-Modifying Treatments in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Real-World Studies

期刊: CNS DRUGS, 2023; 37 (10)

Background The question of whether multiple sclerosis requires life-long disease-modifying treatments (DMTs) remains unanswered. Some studies suggest ......

Sex Differences in Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Preadmission Use of Antiplatelets

期刊: CNS DRUGS, 2023; 37 (4)

AimTo compare safety and functional outcomes of intravenous thrombolysis (IVT) between females and males with acute ischaemic stroke (AIS) in relation......

Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study

期刊: CNS DRUGS, 2023; 37 (10)

Background and Objective Status epilepticus in poststroke epilepsy is a challenging condition because of multiple vascular comorbidities and the advan......

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