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Stress-deprivation induces an up-regulation of versican and connexin-43 mRNA and protein synthesis and increased ADAMTS-1 production in tendon cells in situ

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (1)

Purpose: The proper function of the tenocyte network depends on cell-matrix as well as intercellular communication that is mechanosensitive. Building ......

JIF:2.824

Therapeutic potential of mesenchymal stem cell-derived exosomes as a cell-free therapy approach for the treatment of skin, bone, and cartilage defects

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (2)

Objective: The aim of this study was to collect the articles concerning mesenchymal stem cell (MSC)-derived exosomes for regeneration of bone, cartila......

JIF:2.824

MiR-151b inhibits osteoblast differentiation via downregulating Msx2

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (2)

Purpose: MicroRNA-151b (miR-151b) showed altered expression in ovariectomized rat model of osteoporosis. This study established an ovariectomy-induced......

JIF:2.824

Synergistic effects of myogenic cells and fibroblasts on the promotion of engineered tendon regeneration with muscle derived cells

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Aims Tendon development requires the coordinated interaction of muscles and tendons. Muscle-derived cells (MDCs), a mixed cell population containing b......

JIF:2.824

Clinical, genetic characteristics and treatment outcomes of children and adolescents with osteogenesis imperfecta: a two-center experience

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Background: Osteogenesis imperfecta (OI), is a heritable, heterogeneous connective tissue disorder, characterized by fragile bones. There are conflict......

JIF:2.824

IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Purpose Type V collagen (collagen V) is one of the important components of extracellular matrix (ECM) in pancreas. We previously reported that pre-coa......

JIF:2.824

Implantable biosensors for musculoskeletal health

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (3)

Purpose A healthy musculoskeletal system requires complex functional integration of bone, muscle, cartilage, and connective tissues responsible for bo......

JIF:2.824

Development of a novel knee contracture mouse model by immobilization using external fixation

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (2)

Aims: Several studies have used animal models to examine knee joint contracture; however, few reports detail the construction process of a knee joint ......

JIF:2.824

Regulation of chondrocyte biosynthetic activity by dynamic hydrostatic pressure: the role of TRP channels

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (1)

Introduction: Chondrocytes perceive and respond to mechanical loading as signals that regulate their metabolism. Joint loading exposes chondrocytes to......

JIF:2.824

Attenuation by HSP90 inhibitors of EGF-elicited migration of osteoblasts: involvement of p44/p42 MAP kinase

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Background: We have demonstrated that epidermal growth factor (EGF)-induced migration of osteoblast-like MC3T3-E1 cells is mediated through p44/p42 mi......

JIF:2.824

Sema3A accelerates bone formation during distraction osteogenesis in mice

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Distraction osteogenesis (DO) is a bone regeneration technique used to treat maxillofacial disorders, fracture nonunion, and large bone defects. It is......

JIF:2.824

Effect of cells on spatial quantification of proteoglycans in articular cartilage of small animals

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (6)

Objective: Histochemical characterization of proteoglycan content in articular cartilage is important for the understanding of osteoarthritis pathogen......

JIF:2.824

Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR-29b-3p/PTEN

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (6)

Objective This study investigated the molecular mechanism of whether hUC-MSCs-EVs repressed PTEN expression and activated the PI3K/AKT pathway through......

JIF:2.824

RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Purpose The etiology of adolescent idiopathic scoliosis (AIS) remains unclear. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is im......

JIF:2.824

An inducible model for unraveling the effects of advanced glycation end-product accumulation in aging connective tissues

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Purpose In connective tissues there is a clear link between increasing age and degeneration. Advanced glycation end-products (AGEs) are believed to pl......

JIF:2.824

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