期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 75 ()
Ex situ experimental models have become a main stay in pulmonary research. Organoids and explant systems have uncovered novel stem cell subsets, serve......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 73 ()
As other tubular organs, the embryonic heart develops from an epithelial sheet of cells, referred to as the heart field. The second heart field, which......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 72 ()
Epithelial morphogenesis is guided by mechanical forces and biochemical signals that vary spatiotemporally. As many morphogenetic events are driven by......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 76 ()
Heart failure (HF) is a rapidly growing cardiovascular condition with a prevalence of similar to 40 million individuals worldwide [1]. While HF can be......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 72 ()
Scaffold attachment factor A (SAF-A) or hnRNP U is a nuclear RNA-binding protein with a well-documented role in processing newly transcribed RNA. Rece......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 74 ()
Far from inert structures, our body???s epithelial boundaries engage in a dynamic crosstalk with immune cells that is vital for immune surveillance an......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 77 ()
Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation of chromosomes in mitosis and meiosis. Centromeres organi......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 73 ()
Genome regulation is governed by the dynamics of chromatin modifications. The extensive and diverse array of DNA and histone modifications allow multi......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 75 ()
All organisms are defined by the makeup of their DNA. Over billions of years, the structure and information contained in that DNA, often referred to a......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 75 ()
Experimental evolution with microbial model systems has transformed our understanding of the basic rules underlying ecology and evolution. Experiments......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 72 ()
The making of an embryo and its internal organs entails the spatial coordination of cellular activities. This manifests during tissue morphogenesis as......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 74 ()
Chromosomal instability (CIN) is a hallmark of the most aggressive malignancies. Features of these tumors include complex genomic rearrangements, the ......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 75 ()
Eukaryotic genome organization is ordered and multilayered, from the nucleosome to chromosomal scales. These layers are not static during development,......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 77 ()
Studies of regulatory variation in yeast - at the level of new mutations, polymorphisms within a species, and divergence between species - have provid......
期刊： CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022; 77 ()
Precision medicine, defined as tailoring medical care individually based upon relevant factors, is primarily implemented currently through the use of ......
