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Circular RNAs: Insights into Clinical and Therapeutic Approaches for Various Cancers

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (2)

Background: With the advent of cancer diagnostics and therapeutics, circular RNAs (circRNAs) are swiftly becoming one of the significant regulators of......

Anticancer Compounds from Cyanobacteria and their Implications in Apoptosis

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (10)

Cyanobacteria have been recognized as a rich source of bioactive metabolites with potential biotechnological applications in the pharmacological indus......

Design of Multitarget Inhibitors as Tracheal Smooth Muscle Relaxants

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (3)

Introduction Asthma complications and adverse effects associated with steroidal therapy highlight the need for non-steroidal compounds intercepting as......

Structural Analysis of the Interaction between Bcl-xL and the Noncanonical BH3 Domain of Non-Bcl-2 Family Proteins

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (4)

Anti-apoptotic and anti-autophagic Bcl-2 homologues commonly contain a hydrophobic groove in which the BH3 domain is accommodated. The BH3 domain is u......

Caspase-3 Activators as Anticancer Agents

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (10)

Background The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target......

Ion Channels-related Neuroprotection and Analgesia Mediated by Spider Venom Peptides

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (5)

Ion channels play critical roles in generating and propagating action potentials and in neurotransmitter release at a subset of excitatory and inhibit......

Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (3)

Background Coronavirus Disease 2019 (COVID-19) is a life-threatening and persistent pandemic with high rates of mortality and morbidity. Although a dy......

Current Update on New Delhi Metallo-β-lactamase (NDM) Variants: New Challenges in the Journey of Evolution

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (8)

New Delhi Metallo-beta-lactamase is an enzyme produced by gram-negative bacteria which has become one of the global concerns for physicians to treatin......

Ubiquitous Existence of Cation-Proton Antiporter and its Structure-function Interplay: A Clinical Prospect

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (1)

Sodium, potassium, and protons are the most important ions for life on earth, and their homeostasis is crucially needed for the survival of cells. The......

Dynamic Play between Human N-α-acetyltransferase D and H4-mutant Histones: Molecular Dynamics Study

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (4)

Background: Many N-terminal acetyltransferases (NATs) play important role in the post-translational modifications of histone tails. Research showed th......

Literature Review on Crotalus durissus terrificus Toxins: From a Perspective of Structural Biology and Therapeutic Applications

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (7)

Background: The venom of Crotalus durissus terrificus, as well as its fractions, has intrigued research groups worldwide who are working to isolate, c......

Novel bone Morphogenetic Protein (BMP)-2/4 Consensus Peptide (BCP) for the Osteogenic Differentiation of C2C12 Cells

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (7)

Background Despite the promising clinical potential of bone morphogenetic protein (BMP)-related therapies for bone formation, their side effects warra......

Recent Progress and Challenges in the Development of Edible Vaccines Produced by Genetically Modified Plants

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (9)

Biotechnologists have pioneered the idea of an edible vaccination in recent years. Subunit vaccines, such as those used to create edible vaccines, inv......

Lethal Yellow Mutation Causes Anxiety, Obsessive-compulsive Behavior and Affects the Brain Melanocortin System in Males and Females of Mice

期刊: CURRENT PROTEIN & PEPTIDE SCIENCE, 2023; 24 (4)

Background: The brain melanocortin system regulates numerous physiological functions and kinds of behavior. The agouti protein inhibits melanocortin r......

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