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Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos

期刊: DEVELOPMENTAL CELL, 2022; 57 (1)

How embryos scale patterning according to size is still not fully understood. Through in silico screening and analysis of reaction-diffusion systems t......

JIF:7.602

Bacterial developmental checkpoint that directly monitors cell surface morphogenesis

期刊: DEVELOPMENTAL CELL, 2022; 57 (3)

Bacillus subtilis spores are encased in two concentric shells: an outer proteinaceous coatand an inner peptidoglycan cortex,separated by a membrane. C......

JIF:7.602

Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression

期刊: DEVELOPMENTAL CELL, 2022; 57 (7)

The switch from mitosis to meiosis ensures the successive formation of gametes. However, it remains unclear how meiotic initiation occurs within the c......

JIF:7.602

Condensation of the Drosophila nerve cord is oscillatory and depends on coordinated mechanical interactions

期刊: DEVELOPMENTAL CELL, 2022; 57 (7)

During development, organs reach precise shapes and sizes. Organ morphology is not always obtained through growth; a classic counterexample is the con......

JIF:7.602

Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing

期刊: DEVELOPMENTAL CELL, 2022; 57 (21)

Microtubules have spatiotemporally complex posttranslational modification patterns. How cells interpret this tubulin modification code is largely unkn......

JIF:7.602

?Np63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

期刊: DEVELOPMENTAL CELL, 2022; 57 (24)

Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and metastasis, and they can be generated via epithelial-mesenchymal tran......

JIF:7.602

Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells

期刊: DEVELOPMENTAL CELL, 2022; 57 (2)

Metabolic flexibility is a hallmark of many cancers where mitochondrial respiration is critically involved, but the molecular underpinning of mitochon......

JIF:7.602

YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

期刊: DEVELOPMENTAL CELL, 2022; 57 (2)

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regene......

JIF:7.602

Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis

期刊: DEVELOPMENTAL CELL, 2022; 57 (5)

Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to their mechanical environment through mechanosensitive pathways.......

JIF:7.602

The endophilin curvature-sensitive motif requires electrostatic guidance to recycle synaptic vesicles in vivo

期刊: DEVELOPMENTAL CELL, 2022; 57 (6)

Curvature-sensing mechanisms assist proteins in executing particular actions on various membrane organelles. Here, we investigate the functional speci......

JIF:7.602

Previews YAP-deLIVERing the directions and the fuel

期刊: DEVELOPMENTAL CELL, 2022; 57 (6)

Tissues and cells require fuel and cellular building blocks to respond to proliferative cues. In this issue of Developmental Cell, Vaidyanathan and co......

JIF:7.602

Macrophages, masters of invasion

期刊: DEVELOPMENTAL CELL, 2022; 57 (11)

Macrophages are exceptionally invasive cells. In a recent article in Science, Akhmanova et al. describe a novel mechanism facilitating macrophage infi......

JIF:7.602

Interferon-g resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

期刊: DEVELOPMENTAL CELL, 2022; 57 (15)

Immune surveillance is critical to prevent tumorigenesis. Gliomas evade immune attack, but the underlying mechanisms remain poorly understood. We show......

JIF:7.602

Organ-specific COP1 control of BES1 stability adjusts plant growth patterns under shade or warmth

期刊: DEVELOPMENTAL CELL, 2022; 57 (16)

Under adverse conditions such as shade or elevated temperatures, cotyledon expansion is reduced and hy-pocotyl growth is promoted to optimize plant ar......

JIF:7.602

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