期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (9)
Aldo-keto reductase 1C3 (AKR1C3) plays a role in the detoxification and activation of clinical drugs by catalyzing reduction reactions. There are appr......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (11)
Fenofibrate, a marketed peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, has been widely used for treating severe hypertriglycer......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (3)
Drug absorption from the gastrointestinal tract is often restricted by efflux transport by P-glycoprotein (P-gp) and metabolism by CYP3A4. Both locali......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (7)
Iptacopan (LNP023) is an oral, small-molecule, first-in-class, highly potent proximal complement inhibitor that specifically binds factor B and inhibi......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (1)
The human gut is home to trillions of microorganisms that are responsible for the modification of many orally administered drugs, leading to a wide ra......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (6)
Human absorption, distribution, metabolism, and excretion (hADME) studies represent one of the most important clinical studies in terms of obtaining a......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (8)
Over the past two decades, technological advances in membrane protein structural biology have provided insight into the molecular mechanisms that tran......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (10)
Inclusion of plasma (or plasma proteins) in human hepatocyte uptake studies narrows, but does not close, the gap in in vitro to in vivo extrapolation ......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (3)
Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic human en-zyme involved in the metabolism of many clinically relevant drugs, envi-ronmental toxins......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (5)
Transporters are involved in the movement of many physiologi-cally important molecules across cell membranes and have a sub-stantial impact on the pha......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (6)
The development of safe and effective medications requires a pro-found understanding of their pharmacokinetic (PK) and pharmacody-namic properties. PK......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (9)
Pregnane X receptor (PXR) is a xenobiotic receptor that can be activated by numerous chemicals including endogenous hormones, dietary steroids, pharma......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (12)
Pomotrelvir is an orally bioavailable, target antiviral inhibitor of the main protease (M-pro) of coronaviruses, including severe acute respiratory sy......
期刊： DRUG METABOLISM AND DISPOSITION, 2023; 51 (11)
Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of > 20% of marketed drugs. CYP2D6 expression and activity exhibit high interindividual ......
