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Analysis of the potential of human cultured nasal epithelial cell sheets to differentiate into airway epithelium

期刊: FASEB BIOADVANCES, 2023; 5 (3)

Understanding the expected efficacy and safety of a new regenerative therapy requires analysis of the fate of the transplanted cell graft. We have sho......

Excitation and contraction of cardiac muscle and coronary arteries of brain-dead pigs

期刊: FASEB BIOADVANCES, 2023; 5 (2)

Excitability and contraction of cardiac muscle from brain-dead donors critically influence the success of heart transplantation. Membrane physiology, ......

Nobiletin, a NF-κB signaling antagonist, promotes BMP-induced bone formation

期刊: FASEB BIOADVANCES, 2023; 5 (2)

The NF-kappa B family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF-kappa B s......

Regulation of 5-fluorodeoxyuridine monophosphate-thymidylate synthase ternary complex levels by autophagy confers resistance to 5-fluorouracil

期刊: FASEB BIOADVANCES, 2023; 5 (1)

5-Fluorouracil (5-FU) is a cornerstone drug used to treat colorectal cancer (CRC). However, the prolonged exposure of CRC cells to 5-FU results in acq......

Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70-1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners

期刊: FASEB BIOADVANCES, 2023; 5 (3)

CK2 beta is the non-catalytic modulating part of the S/T-protein kinase CK2. However, the overall function of CK2 beta is poorly understood. Here, we ......

Targeting XBP1 mRNA splicing sensitizes glioblastoma to chemotherapy

期刊: FASEB BIOADVANCES, 2023; 5 (5)

Glioblastoma (GBM) is the most frequent and deadly primary brain tumor in adults. Temozolomide (TMZ) is the standard systemic therapy in GBM but has l......

Human wild-type and D76N β2-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

期刊: FASEB BIOADVANCES, 2023; 5 (11)

beta(2)-microglobulin (beta(2)-m) is a plasma protein derived from physiological shedding of the class I major histocompatibility complex (MHCI), caus......

FtsZ phosphorylation brings about growth arrest upon DNA damage in Deinococcus radiodurans

期刊: FASEB BIOADVANCES, 2023; 5 (1)

The polymerization/depolymerization dynamics of FtsZ play a pivotal role in cell division in the majority of the bacteria. Deinococcus radiodurans, a ......

Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

期刊: FASEB BIOADVANCES, 2023; 5 (9)

Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial......

Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction

期刊: FASEB BIOADVANCES, 2023; 5 (10)

Myocardial infarction (MI) is a lethal disease that causes irreversible cardiomyocyte death and subsequent cardiovascular remodeling. We have previous......

Antioxidants restore store-operated Ca2+ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein

期刊: FASEB BIOADVANCES, 2023; 5 (11)

Store-operated Ca2+ entry (SOCE) is indispensable for intracellular Ca2+ homeostasis in skeletal muscle, and constitutive activation of SOCE causes tu......

Cell migration is impaired in XPA-deficient cells

期刊: FASEB BIOADVANCES, 2023; 5 (2)

Xeroderma pigmentosum (XP) is a hereditary disorder characterized by photosensitivity, predisposition to skin cancers, and neurological abnormalities ......

A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease

期刊: FASEB BIOADVANCES, 2023; 5 (10)

Chronic kidney disease (CKD) involves progressive renal fibrosis, which gradually reduces kidney function and often causes various complications in ex......

Akkermansia muciniphila promotes testosterone-mediated hair growth inhibition in mice

期刊: FASEB BIOADVANCES, 2023; 5 (12)

The beneficial effects of Akkermansia muciniphila (Akk) on gut health and inflammation reduction have been demonstrated; however, scientific evidence ......

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