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Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides

期刊: FEBS LETTERS, 2023; 597 (8)

tRNA methyltransferase 9 (Trm9)-catalysed tRNA modifications have been shown to translationally enhance the DNA damage response (DDR). Here, we show t......

Hsp90 and metal-binding J-protein family chaperones are not critically involved in cellular iron-sulfur protein assembly and iron regulation in yeast

期刊: FEBS LETTERS, 2023; 597 (13)

Systematic studies have revealed interactions between components of the Hsp90 chaperone system and Fe/S protein biogenesis or iron regulation. In addi......

Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity

期刊: FEBS LETTERS, 2023; 597 (11)

An acidic environment in bone is essential for bone metabolism and the production of decarboxylated osteocalcin, which functions as a regulatory hormo......

Manipulating and studying gene function in human pluripotent stem cell models

期刊: FEBS LETTERS, 2023; 597 (18)

Human pluripotent stem cells (hPSCs) are uniquely suited to study human development and disease and promise to revolutionize regenerative medicine. Th......

The glycosylation defect in solute carrier SLC35A2/SLC35A3 double knockout cells is rescued by SLC35A2-SLC35A3 and SLC35A3-SLC35A2 hybrids

期刊: FEBS LETTERS, 2023; 597 (18)

SLC35A2 and SLC35A3 are homologous proteins with postulated nucleotide sugar transporting activities. Unlike SLC35A2, whose specificity for UDP-Gal is......

SUMO in the regulation of DNA repair and transcription at nuclear pores

期刊: FEBS LETTERS, 2023; 597 (22)

Two related post-translational modifications, the covalent linkage of Ubiquitin and the Small Ubiquitin-related MOdifier (SUMO) to lysine residues, pl......

Human-biased TMEM25 expression promotes expansion of neural progenitor cells to alter cortical structure in the developing brain

期刊: FEBS LETTERS, 2023; 597 (21)

Cortical expansion has occurred during human brain evolution. By comparing human and mouse RNA-seq datasets, we found that transmembrane protein 25 (T......

Membranes that make fat: roles of membrane lipids as acyl donors for triglyceride synthesis and organelle function

期刊: FEBS LETTERS, 2023; ()

Triglycerides constitute an inert storage form for fatty acids deposited in lipid droplets and are mobilized to provide metabolic energy or membrane b......

Mitochondrial [2Fe-2S] ferredoxins: new functions for old dogs Vinzent Schulz

期刊: FEBS LETTERS, 2023; 597 (1)

Ferredoxins (FDXs) comprise a large family of iron-sulfur proteins that shuttle electrons from NADPH and FDX reductases into diverse biological proces......

Metal trafficking in the cell: Combining atomic resolution with cellular dimension

期刊: FEBS LETTERS, 2023; 597 (1)

Metals are widely present in biological systems as simple ions or complex cofactors, and are involved in a variety of processes essential for life. Th......

Bioinorganic supramolecular coordination complexes and their biomedical applications

期刊: FEBS LETTERS, 2023; 597 (1)

The field of Bioinorganic Supramolecular Chemistry is an emerging research area including metal-based supramolecules resulting from coordination-drive......

RhoA regulation in space and time

期刊: FEBS LETTERS, 2023; 597 (6)

RhoGTPases are well known for being controllers of cell cytoskeleton and share common features in the way they act and are controlled. These include t......

miR-4734 conditionally suppresses ER stress-associated proinflammatory responses

期刊: FEBS LETTERS, 2023; 597 (9)

Prolonged metabolic stress can lead to severe pathologies. In metabolically challenged primary fibroblasts, we assigned a novel role for the poorly ch......

Protein engineering of antifreeze proteins reveals that their activity scales with the area of the ice-binding site

期刊: FEBS LETTERS, 2023; 597 (4)

Antifreeze proteins (AFPs) protect organisms from freezing by binding to ice crystals to prevent their growth. Here, we have investigated how the area......

Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms

期刊: FEBS LETTERS, 2023; 597 (11)

GPR15 is a G protein-coupled receptor involved in immune disorders such as human immunodeficiency virus-induced enteropathy, multiple sclerosis, and c......

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