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Fullerene C60 reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin-1/IL-1α/HO-1/p53 signaling pathways in rats

期刊: FREE RADICAL RESEARCH, 2023; ()

The objective of this study was to evaluate the effect of fullerene C-60 nanoparticles against 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tiss......

Hypoxia induces dichotomous and reversible attenuation of T cell responses through reactive oxygen species-dependent phenotype redistribution and delay in lymphoblast proliferation

期刊: FREE RADICAL RESEARCH, 2023; 57 (1)

As T cells transit between blood, lymphoid organs, and peripheral tissues, they experience varied levels of oxygen/hypoxia in inflamed tissues, skin, ......

Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury

期刊: FREE RADICAL RESEARCH, 2023; 57 (5)

Myocardial ischemia/reperfusion injury (MIRI) is the principal cause of death and occurs after prolonged blockage of the coronary arteries. Diabetes r......

The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

期刊: FREE RADICAL RESEARCH, 2023; 57 (6-12)

NADPH oxidase 4 (NOX4) inhibition has been reported to mitigate diabetes-induced beta-cell dysfunction and improve survival in vitro, as well as count......

Low-temperature plasma as magic wand to differentiate between the good and the evil

期刊: FREE RADICAL RESEARCH, 2023; 57 (1)

Plasma is the fourth physical state of matter, characterized by an ionized gaseous mixture, after solid, liquid, and gas phases, and contains a wide a......

Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress

期刊: FREE RADICAL RESEARCH, 2023; 57 (3)

Cancer cells exhibit an altered redox balance and aberrant redox signaling due to genetic, metabolic, and microenvironment-associated reprogramming. P......

Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study

期刊: FREE RADICAL RESEARCH, 2023; 57 (6-12)

Chronic obstructive pulmonary disease (COPD) is defined by inflammation and emphysema. Sirtuins (SIRT) are NAD+-dependent histone deacetylases that re......

Free radical scavenging activity of gallic acid toward various reactive oxygen, nitrogen, and sulfur species: a DFT approach

期刊: FREE RADICAL RESEARCH, 2023; 57 (2)

Gallic acid is a well-recognized naturally occurring compound possessing antioxidant activities. The free radical scavenging ability of gallic acid fo......

Hydroperoxyl radical (HOO•) as a reducing agent: unexpected synergy with antioxidants. A review

期刊: FREE RADICAL RESEARCH, 2023; 57 (2)

This review highlights the progress made in recent years in harnessing the peculiar chemistry of the hydroperoxyl, or perhydroxyl, radical (HOO center......

Plasma activated Ringer's lactate solution

期刊: FREE RADICAL RESEARCH, 2023; 57 (1)

Low-temperature plasma (LTP) has been widely used in life science. Plasma-activated solutions were defined as solutions irradiated with LTP, and water......

Mechanistic insight into the free radical scavenging and xanthine oxidase (XO) inhibitor potent of monoacetylphloroglucinols (MAPGs)

期刊: FREE RADICAL RESEARCH, 2023; 57 (3)

Three novel antioxidant candidates based on phenolic polyketide, monoacetylphloroglucinol (MAPG), a natural antibiotic compound produced by plant grow......

Elevated oxidative stress in patients with congenital heart disease and the effect of cyanosis: a meta-analysis

期刊: FREE RADICAL RESEARCH, 2023; ()

Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders. To improve therapy and preventi......

Current understanding of plasma-activated solutions for potential cancer therapy

期刊: FREE RADICAL RESEARCH, 2023; 57 (2)

Cancer therapy consists of multidisciplinary treatment combining surgery, chemotherapy, radiotherapy, and immunotherapy. Despite the elucidation of ca......

Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen

期刊: FREE RADICAL RESEARCH, 2023; 57 (6-12)

Age-related macular degeneration (AMD) is one of an increasing number of diseases that causes irreversible impairment and loss of vision in the elderl......

N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde

期刊: FREE RADICAL RESEARCH, 2023; 57 (6-12)

This study aimed to evaluate the protective role of N-acetylcysteine (NAC) in cells and mice exposed to formaldehyde. For the in vitro study, J774A.1 ......

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