期刊： GENES & DEVELOPMENT, 2022; 36 (9-10)
The differentiation of embryonic stem cells (ESCs) into a lineage-committed state is a dynamic process involving changes in cellular metabolism, epige......
期刊： GENES & DEVELOPMENT, 2022; 36 (1-2)
In this Perspective, Karr et al. propose a new model that diverges from the textbook enhancer-promoter looping paradigm and offer a synthesis of the l......
期刊： GENES & DEVELOPMENT, 2022; 36 (5-6)
Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-cold lung cancer subtype. Historically viewed in the labo......
期刊： GENES & DEVELOPMENT, 2022; 36 (5-6)
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that is a vital regulator of adipogenesis, insulin sensitivity, an......
期刊： GENES & DEVELOPMENT, 2022; 36 (9-10)
One of the mechanisms by which cancer cells acquire hyperinvasive and migratory properties with progressive loss of epithelial markers is the epitheli......
期刊： GENES & DEVELOPMENT, 2022; 36 (19-20)
The Polycomb repressive complexes PRC1, PRC2, and PR-DUB repress target genes by modifying their chromatin. In Drosophila, PRC1 compacts chromatin and......
期刊： GENES & DEVELOPMENT, 2022; 36 (1-2)
Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation ......
期刊： GENES & DEVELOPMENT, 2022; 36 (3-4)
The regeneration of peripheral nerves is guided by regeneration tracks formed through an interplay of many cell types, but the underlying signaling pa......
期刊： GENES & DEVELOPMENT, 2022; 36 (15-16)
The polycomb complex component Bmi1 promotes the maintenance of stem cells in multiple postnatal tissues, partly by negatively regulating the expressi......
期刊： GENES & DEVELOPMENT, 2022; 36 (17-18)
Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in......
期刊： GENES & DEVELOPMENT, 2022; 36 (7-8)
Here, Gualdrini et al. found that loss of H3K9me3 caused by SETDB1 depletion was associated with increased recruitment of CTCF to >1600 DNA binding......
期刊： GENES & DEVELOPMENT, 2022; 36 (17-18)
Telomeric DNA challenges the replisome and requires TRF1 for efficient duplication. TRF1 recruits the BLM helicase, but BLM loss does not explain the ......
期刊： GENES & DEVELOPMENT, 2022; 36 (5-6)
RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-d......
期刊： GENES & DEVELOPMENT, 2022; 36 (7-8)
In this review, Ridge et al. discuss the essential functions of vimentin IFs revealed from studies of Vim(-/-) mice and cells derived from them. More ......
期刊： GENES & DEVELOPMENT, 2022; 36 (17-18)
In this study, Nie et al. performed proteome profiling with label-free quantification in control and single/double-KO cells of USP7 and its closest ho......
