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Exploring Photoredox-Catalyzed (Re)functionalizations with Core-Modified Benziodoxolones

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (1)

Alkynes and nitriles are valuable building blocks in organic synthesis and also have multiple applications in chemical biology and materials science. ......

Synthesis and Reversible H2 Activation by Coordinatively Unsaturated Rhodium NHC Complexes

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (4)

We report the synthesis of coordinatively unsaturated cationic rhodium complexes bearing the sterically encumbered electron-rich NHC ligand IPr*(OMe).......

Transitions in Solvate Crystals of a Tetraaryladamantane

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (9)

Obtaining high-resolution structures of liquid compounds can be difficult. Encapsulating them in the lattice of a larger organic molecule acting as cr......

Metal Template Synthesis of 'Broken' Aromatic Preorganized Terdentate Hosts for the Recognition of Lanthanide Tris-β-Diketonate Guests

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (5)

The binding of the terdentate precursor 2,2 '-(4-methyl-3,5-divinylpyridine-2,6-diyl)bis(1-allyl-5-bromo-1H-benzo[d]imidazole) (1) to the lanthanide c......

A Streamlined, Safe and Sustainable Process for Gemlapodect

期刊: HELVETICA CHIMICA ACTA, 2023; ()

The research efforts to attain a suitable process for the timely delivery of Gemlapodect for initial toxicological and phase 1/2 clinical studies are ......

Advances in Biohybridized Planar Polymer Membranes and Membrane-Like Matrices

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (4)

The past few decades have seen increasing growth in the field of biomimetic membranes and thus also a rapid expansion of their biomedical and technolo......

Tetrel-Centered Exchange Cascades to Decouple Inhibition and Induction of Thiol-Mediated Uptake: Introducing Cell-Penetrating Thiolactones, Focus on Reversible Michael Acceptor Dimers

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (6)

This study adds thiolactones to the collection of cascade exchangers (CAXs) and reports with dynamic covalent Michael acceptor dimers the first CAXs t......

Investigating the Cusp Between Dendritic and Supermolecular Architectures in Self-Organizing Liquid Crystals

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (7)

Liquid Crystals are thought of as being complex fluids, underpinned by self-assembly and self-organisation within partially ordered fluids, and which ......

Sydnone-Cyanines as Clickable Probes for Fluorescent Labelling

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (3)

The synthesis of four clickable sydnone-heptamethine cyanine derivatives is described in this article. The synthetic route is based on a palladium-cro......

The p-Molecular Complex of Biphenylene and Tetracyanoethylene

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (9)

The investigation of the biphenylene (BP)-tetracyanoethylene (TCNE) & pi;-molecular complex is reported. The first study on this complex appeared ......

Alternative Synthesis of 5-(1H-Pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl) oxy]pyridazin-3-yl}phenol

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (3)

A scalable and environmentally benign route to the free base of branaplam, a small molecule splicing modulator, was identified and developed. This alt......

Immobilized Rose Bengal as Photocatalyst for Metal-Free Thiocyanation of Azaheterocycles under Continuous Flow Conditions

期刊: HELVETICA CHIMICA ACTA, 2023; ()

The immobilization of Rose Bengal onto Merrifield resin and its application in the light-driven metal-free thiocyanation of azaheterocycles in continu......

Optimizing Phosphate Couplings for Dolichyl Diphosphochitobiose to Enable Protein N-Glycosylation Studies

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (12)

Herein we report an optimized synthesis for dolichyl diphosphochitobiose (GlcNAc(2)-PP-Dol(25)), a probe useful for biochemical and structural studies......

Synthesis of the Multidrug Reversal Agent Ko143 and Its Parent Natural Product Fumitremorgin C

期刊: HELVETICA CHIMICA ACTA, 2023; 106 (2)

Ko143 is a tetracyclic, synthetic analog of the fungal metabolite fumitremorgin C. Ko143 is a potent and specific inhibitor of the membrane-bound effl......

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