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Multicentre validation of a modified EUCAST MIC testing method and development of associated epidemiologic cut-off (ECOFF) values for rezafungin

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (1)

Objectives Rezafungin EUCAST MIC testing has been associated with notable inter-laboratory variation, which prevented ECOFF setting for C. albicans. W......

Drug resistance in children and adolescents with HIV in Panama

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (2)

This study evaluates the impact of the presence of antiretroviral resistance mutations in an HIV-infected paediatric cohort in Panama from 2019-2020. ......

Efficacy of ceftazidime/avibactam in various combinations for the treatment of experimental osteomyelitis in rabbits caused by OXA-48-/ESBL-producing Escherichia coli

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (5)

Background While the treatment of ESBL-producing Enterobacterales osteomyelitis relies on carbapenems, the optimal regimen for OXA48 types remains unc......

CATALYST: challenging antibiotic allergy status

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (5)

Objectives To develop a transferable process, CATALYST (challenging antibiotic allergy status), to assess and challenge penicillin allergy status of i......

A multi-site, international laboratory study to assess the performance of penicillin susceptibility testing of Staphylococcus aureus

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (6)

Objectives There is clinical uncertainty over the optimal treatment for penicillin-susceptible Staphylococcus aureus (PSSA) infections. Furthermore, t......

Streptococcus pneumoniae serotyping and antimicrobial susceptibility: assessment for vaccine efficacy in Canada after the introduction of PCV13

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 ()

Background Streptococcus pneumoniae continues to be an important bacterial pathogen associated with invasive (e.g. bacteraemia, meningitis) and non-in......

Prevalence of antibiotic prescribing in COVID-19 patients in China and other low- and middle-income countries during the pandemic (December 2019-March 2021): a systematic review and meta-analysis

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (12)

Objectives Low- and middle-income countries (LMICs) are particularly vulnerable to the threat of antimicrobial resistance (AMR). Use of antibiotics to......

Development and validation of a resazurin assay for in vitro susceptibility testing of Actinomadura madurae: a common causative agent of actinomycetoma

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (1)

Objectives Actinomycetoma is a chronic granulomatous disease affecting skin, subcutaneous tissue, fascia, muscle and bones. With increasing resistance......

Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (4)

Background Cloxacillin is the first-line treatment for methicillin-susceptible staphylococcal infective endocarditis (IE). The recommended dose is 12 ......

The primary pharmacology of ceftazidime/avibactam: microbiology from clinical studies, and development of resistance during treatment

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (4)

As one of a series of thematically linked reviews of the primary pharmacology of the beta-lactam/beta-lactamase inhibitor combination, ceftazidime/avi......

Evaluation of the tolerance of ceftriaxone by subcutaneous route in patients=75 years old in geriatric departments: a prospective observational study

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023; 78 (6)

Objectives: The subcutaneous (SC) route provides an alternative to the IV or oral route for drug administration in the elderly. The benefits of SC adm......

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