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Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 134 ()

Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory my-opathies (IIM). However, up to 40% of IIM ......

Clinical utility of measuring CD4+ T follicular cells in patients with immune dysregulation

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 140 ()

Mechanistic studies of autoimmune disorders have identified circulating T follicular helper (cTfh) cells as drivers of autoimmunity. However, the quan......

The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 140 ()

Objective: Systemic sclerosis (SSc) is a rare but deadly disease characterized by autoimmunity, vasculopathy, and fibrosis. Fibrotic complications ass......

Comprehensive description of adult-onset Still's disease after COVID-19 vaccination

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 134 ()

Cases of adult-onset Still's disease (AOSD) have been reported after COVID-19 vaccination. Here we provide a comprehensive description and analysis of......

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 139 ()

Butyrophilins are surface receptors belonging to the immunoglobulin superfamily. While several members of the butyrophilin family have been implicated......

Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 139 ()

Obesity-induced chronic inflammation has been linked to several autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and multiple scl......

Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 141 ()

Systemic lupus erythematosus (SLE) is an autoimmune disease with the characterized presence of autoantibodies and resulting in multiple organ damage, ......

Salivary gland epithelial cell in Sjogren?s syndrome: Metabolic shift and altered mitochondrial morphology toward an innate immune cell function

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 136 ()

Salivary gland epithelial cells (SGEC) are the main targets of the autoimmune reactivity in Sjo center dot gren's syndrome (SS). This study aimed to i......

HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 138 ()

Hepatocyte nuclear factor 4 a (HNF4a), a transcription factor (TF) essential for embryonic development, has been recently shown to regulate the expres......

Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 139 ()

Objective: Systemic lupus erythematosus (SLE) is a highly female-biased systemic autoimmune disease, but the molecular basis for this female bias rema......

Involvement of trained immunity during autoimmune responses

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 137 ()

Recently, it has been described that innate immune cells such as monocytes, macrophages, and natural killer cells can develop a non-specific immune re......

Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 140 ()

Background: The role of autoreactive T cells on the course of Coronavirus disease-19 (COVID-19) remains elusive. Type II pneumocytes represent the mai......

Pattern recognition receptor mediated innate immune response requires a Rif-dependent pathway

期刊: JOURNAL OF AUTOIMMUNITY, 2023; 134 ()

Small GTPases play critical roles in cell morphology, movement, and adhesion by dynamic regulation of actin cytoskeleton. The small Rho GTPase Rif/Rho......

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