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Hypokalemia and Hyponatremia in Adult Patients Receiving Voriconazole Therapeutic Drug Monitoring

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; ()

Hypokalemia and hyponatremia are common but easily ignored adverse events in treatment with voriconazole (VCZ) that can lead to serious consequences. ......

Comparison of Clinical Effectiveness Between Ambroxol and N-Acetylcysteine in Surgical Patients: A Retrospective Cohort Study

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (2)

Postoperative pulmonary complications (PPCs) are a major cause of postoperative morbidity, mortality, and longer hospital stays. Expectorants are wide......

Ivermectin's Role in the Prevention of COVID-19: A Systematic Review and Meta-Analysis

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (3)

This systematic review was performed to determine the population that benefited from prophylactic ivermectin. Seven databases of health-related studie......

Direct Oral Anticoagulants: An Updated Systematic Review of Their Clinical Pharmacology and Clinical Effectiveness and Safety in Patients With Nonvalvular Atrial Fibrillation

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (4)

Direct oral anticoagulants have been an increasingly used class of drugs in the setting of nonvalvular atrial fibrillation, defying vitamin K antagoni......

Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (12)

Nutraceuticals like alpha-lipoic acid (ALA) may have potential benefits as prophylactic agents for adolescent migraine, with fewer adverse events than......

DOAC Dosing Discordance Using Different Estimates of Kidney Function and Outcomes

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (9)

Direct oral anticoagulants (DOACs) are indicated for the prevention of stroke in nonvalvular atrial fibrillation. Although Food and Drug Administratio......

Evaluation of Truncated AUC as an Alternative Measure to Assess Pharmacokinetic Comparability in Bridging Biologic-Device Using Prefilled Syringes and Autoinjectors

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (12)

Pharmacokinetic (PK) comparisons between therapeutic biologics have largely been based on the total area under the concentration-time curve (AUC) and ......

Pediatric Efficacy Extrapolation in Drug Development Submitted to the US Food and Drug Administration 2015-2020

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (3)

Pediatric extrapolation plays a key role in the availability of reliable pediatric use information in approved drug labeling. This review examined the......

Revisiting β-Lactams for Treatment of Urinary Tract Infections: Assessing Clinical Outcomes of Twice-Daily Cephalexin for Empiric Treatment of Uncomplicated Urinary Tract Infections

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (3)

The 2011 Infectious Diseases Society of America guidelines for treatment of uncomplicated urinary tract infections (UTIs) recommend non-beta-lactam an......

Extrapolation of Adult Efficacy Data to Pediatric Systemic Lupus Erythematosus: Evaluating Similarities in Exposure-Response

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (1)

To streamline drug development, the United States Food and Drug Administration (FDA) can consider the extrapolation of adult efficacy data to children......

Landscape and Regulatory Perspective on Oncology Drugs in Pregnancy

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 ()

Cancers affecting pregnant women include breast cancer, melanoma, thyroid cancer, cervical cancer, lymphomas, and leukemias. The medical management of......

Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2023; 63 (9)

Cilofexor is a nonsteroidal farnesoid X receptor agonist in clinical development for treatment of nonalcoholic steatohepatitis. This work characterize......

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