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Characteristic fragmentation of polyunsaturated fatty acids with allylic vicinal diols in positive-ion LC/ESI-MS/MS

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (6)

A characteristic fragmentation was observed for PUFAs that contain allylic vicinal diol maresin 2), which were derivatized with N,Ndimethylethylenedia......

Eicosapentaenoic acid reduces the proportion of IL-17A-producing T cells in a 3D psoriatic skin model

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (9)

Psoriasis is a skin disease presenting as erythematous lesions with accentuated proliferation of epidermal keratinocytes, infiltration of leukocytes, ......

PCSK9 and the nervous system: a no-brainer?

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (9)

In the past 20 years, PCSK9 has been shown to play a pivotal role in LDL cholesterol metabolism and cardiovascular health by inducing the lysosomal de......

Disease-related PSS1 mutant impedes the formation and function of osteoclasts

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (11)

Phosphatidylserine (PS) is an acidic phospholipid that is involved in various cellular events. Heterologous dominant mutations have been identified in......

Olatp trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (12)

Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfoldi......

Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (5)

Biogenesis of lipid droplets (LDs) in various cells plays an important role in various physiological and pathological processes. However, the function......

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (9)

Oxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in athero-sclerosis. Though there have been many studies on the athero......

Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (7)

The introduction of mass spectrometrybased proteomics has revolutionized the high-density lipoprotein (HDL) field, with the description, characterizat......

High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (9)

Biallelic pathogenic variants of the Sar1b whose central phenotype is the inability to secrete chylomicrons. Patients with CRD experience numerous cli......

LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (11)

Metabolic changes in adrenocortical steroids and medullary catecholamines characterize adrenal tumors, but they are measured using different analytica......

Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (10)

The newly identified bacterium Dysosmobacter welbionisJ115(T) improves host metabolism in high-fat diet (HFD)-fed mice. To investigate mechanisms, we ......

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (11)

Although pregnant women's fish con-sumption is beneficial for the brain development of the fetus due to the DHA in fish, seafood also contains methylm......

The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (5)

Peroxisomes are single-membrane boun-ded organelles that in humans play a dual role in lipid metabolism, including the degradation of very long -chain......

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (2)

Coordinated lipid metabolism contributes to maintaining skin homeostasis by regulating skin barrier formation, immune reactions, thermogenesis, and pe......

2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites

期刊: JOURNAL OF LIPID RESEARCH, 2023; 64 (8)

Vitamin D analysis by MS faces several analytical challenges, including inefficient ionization, nonspecific fragmentation, interferences from epi-mers......

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