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Terpenoids from the Sponge Sarcotragus sp. Collected in the South China Sea

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (2)

Sarcotragusolides A-D (1-4), four new butenolide sesterterpenes featuring a rare methyl-transferred 6/6/6-tricyclic fused ring system with a butyrolac......

Euphohelides A-C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (4)

Three unreported ent-abietane-type norditerpene lactones, euphohelides A-C (1-3), and 11 known analogs (4- 14) were isolated from the whole plants of ......

Strophioblachins A-K, Structurally Intriguing Diterpenoids from Strophioblachia fimbricalyx with Potential Anticardiac Hypertrophic Inhibitory Activity

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (5)

Three new rearranged diterpenoids, strophiobla-chins A-C (1-3), eight new diterpenoids, strophioblachins D-K (4-11), and seven previously described di......

Fatty Acid Conjugated Chalcones as Tubulin Polymerization Inhibitors: Design, Synthesis, QSAR, and Apoptotic and Antiproliferative Activity

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (5)

Cancer is often associated with an aberrant increase in tubulin and microtubule activity required for cell migration, invasion, and metastasis. A new ......

Complexation of Apigenin and Oxymatrine Leading to Enhanced Anti-inflammatory Activity

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (5)

Apigenin (APG) is a well-known dietary flavonoid with multiple bioactivities, but its poor aqueous solubility may result in low oral bioavailability a......

The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (6)

Colorectal cancer (CRC) is an exceptionally deadly disease,whereaseffective therapeutic drugs for CRC have declined over the past fewdecades. Natural ......

Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (6)

Chemical investigation of the twigs of Cleistanthussumatranus (Phyllanthaceae) led to the isolation of 10 undescribedlignans,sumatranins A-J (1-10). C......

Orellanine: From Fungal Origin to a Potential Future Cancer Treatment

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (6)

Fungal metabolites represent an underutilizedresource in the developmentof novel anticancer drugs. This review will focus on the promisingfungal nephr......

Pseudo-Enantiomeric Paraphaeolactones and Their Biosynthetic Derivatives from Paraphaeosphaeria sp. KT4192: A Proposition of a Favorskii Rearrangement for Their Biosynthesis

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (7)

Paraphaeolactones A1, A2, B1, and B2 (1-4, respectively), known arthropsadiol D (5),massariphenone (6) and its positional isomer 7, and massarilactone......

Semisynthesis of Linariophyllenes A-C and Rumphellolide H, Structure Revisions and Proposed Biosynthesis Pathways

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (10)

The first semisynthetic routes toward terrestrial anti-inflammatory natural products linariophyllene A-C and the refined route toward marine natural p......

Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (11)

The emergence of drug-resistant viruses is a serious concern in current chemotherapy for human immunodeficiency virus type-1 (HIV-1) infectious diseas......

Pharmacokinetics and Metabolism Investigation of Oleocanthal

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; ()

Oleocanthal is a secoiridoid found in olive oil, which lately gained great scientific interest due to its important pharmacological spectrum and biolo......

ent-Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp.

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 86 (11)

Metabolites 1 and 2, isolated from cultures of the basidiomycete Resupinatus sp. BCC84615, collected in a tropical forest in northeastern Thailand, sh......

Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from Physalis angulata var. villosa

期刊: JOURNAL OF NATURAL PRODUCTS, 2023; 87 (1)

The glucose transporter 1 (GLUT1) protein is involved in the basal-level absorption of glucose in tumor cells. Inhibiting GLUT1 decreases tumor cell p......

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