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Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023; 119 ()

Immunogenicity has been a major concern in the safety evaluation of therapeutic proteins. The assessment of the unwanted immunogenicity of the therape......

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023; 122 ()

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we rev......

Adaptation of closed-chest infarction porcine model to adult Pannon minipigs

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023; 123 ()

The aim of the recent study was to collect data on the genotype characteristics of the Hungarian self-bred Pannon minipigs by adapting a standardized ......

Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023; 120 ()

Insulin resistance (IR) is the main feature of prediabetes (PD), which ultimately leads to diabetes. High-dose streptozotocin-treated rodents often sh......

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