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2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide analogs as potential antagonists of Urotensin II receptor

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (1)

The purpose of the articleTo identify novel small molecule antagonists of Urotensin II receptor with acceptable pharmacological profile.Materials and ......

Hypoxia and acidity regulate immune checkpoint molecule and IFN-β expression in non-small cell lung cancer cell lines

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (2)

Purpose: Non-small cell lung cancer (NSCLC) is one of the most lethal tumors in humans. Immunotherapy with immune checkpoint inhibitors (ICIs) has rev......

Synthesis, in silico and in vitro anti-cancer studies of phosphorylated derivatives of didanosine targeting MDA-MB-231 breast cancer cell lines

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (6)

A series of new phosphorylated derivatives of didanosine were designed, synthesized and evaluated their anticancer effects on human breast cancer cell......

Estrogen receptors as potential therapeutic target in endometrial cancer

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (1)

Endometrial cancer (EC) is one of the most common gynecological carcinomas in both developed and developing countries. Majority of the gynecological m......

Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE)

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (5)

Acetylcholinesterase (AChE) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. This enzyme is often the target of m......

Sepsis modulates aortic AT1 and P2Y6 receptors to produce vascular hyporeactivity in mice

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (2)

PurposeHyporeactivity to vasopressors leading to multiple organ failure is a serious clinical implication in sepsis. Though the regulatory role of pur......

Cerebrolysin provides effective protection on high glucose-induced neuropathy in cultured rat dorsal root ganglion neurons

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (5)

Cerebrolysin, an endogenous peptide with neuroprotective and neurotrophic properties, indicated to be beneficial on diabetic neuropathy by preliminary......

Quantitative structure activity relationship (QSAR) modeling study of some novel thiazolidine 4-one derivatives as potent anti-tubercular agents

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (3)

This study aims to develop a QSAR model for Antitubercular activity. The quantitative structure-activity relationship (QSAR) approach predicted the th......

The route of autophagy regulation by osteopontin: a review on the linking mechanisms

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (4)

Autophagy is a dynamic intracellular process of protein degradation, which is mostly triggered by nutrient deprivation. This process initiates with th......

New synthetic derivatives of isoindoline-dione: synthesis, neuroprotection assay and impact on the expression level of oxidative stress-related genes in neuronal-like cell line

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (6)

PurposeOxidative stress can damage cells and cause age-related illnesses such as Alzheimer's, Parkinson's, and Huntington's. This study looked at newl......

An overview of the molecular and clinical significance of the angiopoietin system in leukemia

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (2)

The angiogenesis efficacy in solid tumors and hematological malignancies has been identified for more than twenty years. Although the exact role of an......

MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (6)

Objective: This study investigated the effects of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlyin......

Verapamil modulates NFAT2 to inhibit tumor growth and potentiates PD1ab immune checkpoint inhibitor therapy in cervical cancer treatment

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; 43 (4)

PurposeCurrent evidence suggests a high co-prevalence of hypertension and cervical cancer. Accordingly, blood pressure control is indicated during ant......

Rhein protects retinal Muller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway

期刊: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2023; ()

Oxidative stress, inflammation and apoptosis are important pathogenic factors of diabetic retinopathy (DR). In the current study, we aimed to evaluate......

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