期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (8)
In this study, a series of derivatives of thiazolyl-pyrazole hybrid structures were designed to search for new heterocyclic compound-based antitumor a......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (9)
Definition of the relationship between drug protein adduct formation (haptenation) and development of immunological adverse drug reactions (drug hyper......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (8)
Tuberculosis is an infectious disease that has re-emerged in multiple/extensively resistant forms (MDR/XDR) since 1990's creating threat to the mankin......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (8)
Zeste homolog enhancer 2 (EZH2) is one of the core catalytic subunits of PRC2, which mainly mediates histone H3K27 trimethylation to regulate the expr......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (11)
As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (12)
In the last years, the emergence and spread of viral infections have been described with increased frequency and becomes a serious problem. The develo......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (12)
Maternal embryonic leucine zipper kinase (MELK) is a serine-threonine kinase. Several studies have revealed its role as a regulator in the tumorigenes......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (3)
There are a plethora of antibiotic resistance cases and humans are marching towards another big survival test of evolution along with drastic climate ......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (6)
PI3K delta signaling promotes cancer proliferation. To model this interesting target, we collected 79 PI3K delta inhibitors of known bioactivities and......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (10)
Arginase is a potential target of drugs against Leishmania spp. Natural products can be a source of arginase inhibitors. This study has investigated w......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (7)
Traditional targets and modalities that have provided rich substrates for medicine design and decades of productive industrial and academic research a......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (7)
For much of the past 20 years, MDM2 has been pursued as a cancer therapeutic target. Small molecule inhibitors that block the MDM2-p53 protein-protein......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (7)
Pharmacokinetic properties of our first-generation HIF-2a antagonist PT2385, including modest solubility, resulted in a high recommended phase 2 dose ......
期刊： MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (5)
Inflammation in the central nervous system is associated with numerous neurological disorders, including multiple sclerosis, Parkinson's disease, Alzh......
