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Coordinated reprogramming of metabolism and cell function in adipocytes from proliferation to differentiation

期刊: METABOLIC ENGINEERING, 2022; 69 ()

Adipose tissue plays a major role in regulating lipid and energy homeostasis by storing excess nutrients, releasing energetic substrates through lipol......

JIF:9.835

G6P-capturing molecules in the periplasm of Escherichia coli accelerate the shikimate pathway

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Escherichia coli, the most studied prokaryote, is an excellent host for producing valuable chemicals from renewable resources as it is easy to manipul......

JIF:9.835

Secretory production of spider silk proteins in metabolically engineered Corynebacterium glutamicum for spinning into tough fibers

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Spider dragline silk is a remarkable fiber made of unique proteins-spidroins-secreted and stored as a concentrated aqueous dope in the major ampullate......

JIF:9.835

Rational orthologous pathway and biochemical process engineering for adipic acid production using Pseudomonas taiwanensis VLB120

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Microbial bioprocessing based on orthologous pathways constitutes a promising approach to replace traditional greenhouse gas- and energy-intensive pro......

JIF:9.835

Multiplex genome editing of mammalian cells for producing recombinant heparin

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Heparin is an essential anticoagulant used for treating and preventing thrombosis. However, the complexity of heparin has hindered the development of ......

JIF:9.835

Live isolation of naive ESCs via distinct glucose metabolism and stored glycogen

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Naive and primed pluripotent stem cells recapitulate the peri- and post-implantation development, respectively. Thus, investigation of distinct traits......

JIF:9.835

Guiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry

期刊: METABOLIC ENGINEERING, 2022; 71 ()

Lignin is an important structural component of terrestrial plants and is readily generated during biomass fractionation in lignocellulose processing f......

JIF:9.835

Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy

期刊: METABOLIC ENGINEERING, 2022; 71 ()

High levels of anthropogenic CO2 emissions are driving the warming of global climate. If this pattern of increasing emissions does not change, it will......

JIF:9.835

Single cell mutant selection for metabolic engineering of actinomycetes

期刊: METABOLIC ENGINEERING, 2022; 73 ()

Actinomycetes are important producers of pharmaceuticals and industrial enzymes. However, wild type strains require laborious development prior to ind......

JIF:9.835

Resource-allocation constraint governs structure and function of microbial communities in metabolic modeling

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Predictive modeling tools for assessing microbial communities are important for realizing transformative capabilities of microbiomes in agriculture, e......

JIF:9.835

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we id......

JIF:9.835

Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production

期刊: METABOLIC ENGINEERING, 2022; 73 ()

Diterpenoids display a large and structurally diverse class of natural compounds mainly found as specialized plant metabolites. Due to their diverse b......

JIF:9.835

Combinatorial pathway engineering of Bacillus subtilis for production of structurally defined and homogeneous chitooligosaccharides

期刊: METABOLIC ENGINEERING, 2022; 70 ()

Chitooligosaccharides (COSs) have a widespread range of biological functions and an incredible potential for various pharmaceutical and agricultural a......

JIF:9.835

Improved methylation in E. coli via an efficient methyl supply system driven by betaine

期刊: METABOLIC ENGINEERING, 2022; 72 ()

Methylation reactions are involved in the biosynthesis of various natural molecules, in which S-adenosyl-L-methionine (SAM) acts as the principal biol......

JIF:9.835

Metabolic engineering for the utilization of carbohydrate portions of lignocellulosic biomass

期刊: METABOLIC ENGINEERING, 2022; 71 ()

The petrochemical industry has grown to meet the need for massive production of energy and commodities along with an explosive population growth; howe......

JIF:9.835

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