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Activation of TRPV4 stimulates transepithelial K+ secretion in rat epididymal epithelium

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (2)

The maturation of sperms is dependent on the coordinated interactions between sperm and the unique epididymal luminal milieu, which is characterized b......

JIF:3.459

Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (8)

A successful pregnancy is a complicated process that builds upon two aspects of the maternal immune system that need to be balanced. As one of the ind......

JIF:3.459

Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (3)

Changes in cell phenotype are thought to occur through the expression of groups of co-regulated genes within topologically associated domains (TADs). ......

JIF:3.459

On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (4)

About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of either meiotic or mitotic origin. Abnormalities of mitotic orig......

JIF:3.459

Sperm degradation after vasectomy follows a sperm chromatin fragmentation-dependent mechanism causing DNA breaks in the toroid linker regions

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 29 (9)

Vasectomy is a widely used surgical technique creating an obstructive azoospermia. Although sperm cannot be ejaculated, the testis maintains sperm pro......

JIF:3.459

Thermotaxis of mammalian sperm

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (8)

Sperm are guided through the female reproductive tract. A temperature difference of about 2 degrees C exists between the storage site and fertilizatio......

JIF:3.459

Transcriptional profiles of genes related to mitochondrial aging in placental pathologies

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 29 (9)

As the placenta develops across gestation, the mitochondria and other organelles like the endoplasmic reticulum (ER) must continue to adapt to stresso......

JIF:3.459

Host defense functions of the epididymal amyloid matrix

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (12)

The epididymal lumen is an immunologically distinct environment. It maintains tolerance for the naturally antigenic spermatozoa to allow their maturat......

JIF:3.459

Acrosomal alkalinization occurs during human sperm capacitation

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (3)

Mammalian sperm capacitation is a prerequisite for successful fertilization. Capacitation involves biochemical and physiological modifications of sper......

JIF:3.459

A rare frameshift mutation in SYCP1 is associated with human male infertility

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (4)

Proper assembly of the synaptonemal complex is essential for successful meiosis, and impairments in the process lead to infertility. Meiotic transvers......

JIF:3.459

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (7)

A distinct age-related alteration in the uterine environment has recently been identified as a prevalent cause of the reproductive decline in older fe......

JIF:3.459

Pathogenic variant in ACTL7A causes severe teratozoospermia characterized by bubble-shaped acrosomes and male infertility

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (8)

Teratozoospermia is a common factor associated with male infertility. However, teratozoospermia characterized by bubble-shaped acrosomes (BSAs) has no......

JIF:3.459

Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (10)

Follicles are the functional unit of the ovary and several methods have been developed to grow follicles ex vivo, which recapitulate key events of oog......

JIF:3.459

Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 29 (9)

During ejaculation, cauda epididymal spermatozoa are suspended in a protein-rich solution of seminal plasma, which is composed of proteins mostly secr......

JIF:3.459

Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions

期刊: MOLECULAR HUMAN REPRODUCTION, 2022; 28 (11)

COVID-19 exerts systemic effects that can compromise various organs and systems. Although retrospective and in silico studies and prospective prelimin......

JIF:3.459

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