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PI-RADS-Based Segmented Threshold of PSMA-PET SUVmax Is Better than Traditional Fixed Threshold for Diagnosing Clinically Significant Prostate Cancer Especially for PI-RADS 3 Lesions

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (5)

ObjectivesOur purpose was to compare the performance of prostate-specific membrane antigen (PSMA)-positron emission tomography (PET) traditional fixed......

Towards Characterization of Skin Melanoma in the Clinic by Electron Paramagnetic Resonance (EPR) Spectroscopy and Imaging of Melanin

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; ()

The incidence of melanoma is continuously increasing over time. Melanoma is the most aggressive skin cancer, significantly reducing quality of life an......

A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (5)

Background Intraoperative molecular imaging (IMI) uses tumor-targeted optical contrast agents to improve identification and clearance of cancer during......

Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

Purpose In vivo detection of transactivation response element DNA binding protein-43 kDa (TDP-43) aggregates through positron emission tomography (PET......

Predicting Soft Tissue Sarcoma Response to Neoadjuvant Chemotherapy Using an MRI-Based Delta-Radiomics Approach

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (4)

Objectives To evaluate the performance of machine learning-augmented MRI-based radiomics models for predicting response to neoadjuvant chemotherapy (N......

Accuracy and Precision of Iodine Quantification in Subtracted Micro-Computed Tomography: Effect of Reconstruction and Noise Removal Algorithms

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (6)

PurposeTo evaluate the effect of reconstruction and noise removal algorithms on the accuracy and precision of iodine concentration (C-I) quantified wi......

Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; ()

Purpose In cancer immunotherapy, the blockade of the interaction between programmed death-1 and its ligand (PD-1:PD-L1) has proven to be one of the mo......

Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (1)

Introduction Cancer surgery has multiple challenges including localizing small lesions, ensuring negative margins, and identifying synchronous cancers......

Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (2)

Purpose TRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca2+-permeable cationic channels and it has been implicated i......

Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

Purpose Small molecule inhibitors that target oncogenic driver kinases are an important class of therapies for non-small cell lung cancer (NSCLC) and ......

Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecu......

Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

Purpose (S)-4-(3-[F-18]Fluoropropyl)-L-glutamic acid ([F-18]FSPG) is an L-glutamate derivative used as a PET biomarker to assess intracellular redox s......

Detection and Typing of Renal Amyloidosis by Fluorescence Spectroscopy Using the Environmentally Sensitive Fluorophore K114

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (1)

Purpose To demonstrate that spectral analysis using the K114 fluorophore can detect and differentiate AL and AA renal amyloidosis. Procedures Kidney b......

Synthesis and Preliminary Evaluation of an 18F-labeled Oleate Analog to Image Fatty Acid Beta-Oxidation in the Absence of Metabolic Defluorination

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

Purpose Fatty acid oxidation (FAO) is a key parameter for evaluating cardiovascular, oncologic, neurologic, and other metabolic diseases. Several sing......

Immuno-PET Monitoring of CD8+ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a 89Zr Anti-CD8+ Mouse Minibody in EMT6 Syngeneic Tumor Mouse

期刊: MOLECULAR IMAGING AND BIOLOGY, 2023; 25 (3)

Purpose The presence and functional competence of intratumoral CD8(+) T cells is often a barometer for successful immunotherapeutic responses in cance......

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