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Investigation of the antioxidant effect of Chrysin in an experimental cataract model created in chick embryos

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Cataract, which occurs as a result of lens opacification, is one of the most common causes of vision loss. In the literature, deterioration o......

Addressing bias in manual segmentation of spheroid sprouting assays with U-Net

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Angiogenesis research faces the issue of false-positive findings due to the manual analysis pipelines involved in many assays. For example, t......

Toll-like receptor-4 expression and oxidative stress in ocular rosacea

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: To investigate systemic and ocular toll-like receptor (TLR)-4 expression and its association with oxidative stress markers in ocular rosacea ......

Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: The cystine/glutamate antiporter is involved in the export of intracellular glutamate in exchange for extracellular cystine. Glutamate is the......

Timolol maleate, a β blocker eye drop, improved edema in a retinal vein occlusion model

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: To investigate the therapeutic effects of eye drops, namely, timolol maleate, a beta-adrenergic receptor antagonist, and latanoprost, a prost......

The Association between Cholesterol Levels and Severity of Normal Tension Glaucoma

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: To evaluate the serum lipid levels, including total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) of patient......

Aqueous humor cytokines are associated with baseline optical coherence tomography imaging features in eyes with diabetic macular edema

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: This study aimed to assess the association between cytokine expression and optical coherence tomography (OCT) features of diabetic macular ed......

Distribution of TGFBI variants in patients with early onset glaucoma

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: To describe a novel association of TGFBI variants with congenital glaucoma in a family with GAPO (growth retardation, alopecia, pseudoanodont......

USH2A mutational spectrum causing syndromic and non-syndromic retinal dystrophies in a large cohort of Mexican patients

期刊: MOLECULAR VISION, 2023; 29 ()

Background: Mutations in the USH2A gene are the leading cause of both non-syndromic autosomal recessive retinitis pigmentosa (RP) and Usher syndrome, ......

The apoptotic and anti-proliferative effect of Lysyl oxidase propeptide in Y79 human retinoblastoma cells

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Retinoblastoma (RB) caused by the mutation of the RB1 gene is one of the most common ocular malignancies in children The propeptide region of......

Novel pathogenic variants in Tubulin Tyrosine Like 5 (TTLL5) associated with cone-dominant retinal dystrophies and an abnormal optical coherence tomography phenotype

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Autosomal recessive cone and cone-rod dystrophies (CD/CRD) are inherited forms of vison loss. Here, we report on and correlate the clinical p......

Genetic causes of inherited retinal diseases among Israeli Jews of Ethiopian ancestry

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: This study sought to describe the phenotype frequency and genetic basis of inherited retinal diseases (IRDs) among a nationwide cohort of Isr......

PET imaging of retinal inflammation in mice exposed to blue light using [18F]-DPA-714

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Positron emission tomography (PET) is widely used in high-precision imaging, which may provide a simple and noninvasive method for the detect......

Cytokines and chemokines involved in HLA-B27-positive ankylosing spondylitis-associated acute anterior uveitis

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: Acute anterior uveitis (AAU) is the most common extra-articular symptom of ankylosing spondylitis (AS). This study aims to reveal the cytokin......

Downregulation of SIRT6 and NMNAT2 is associated with proliferative diabetic retinopathy

期刊: MOLECULAR VISION, 2023; 29 ()

Purpose: To determine the expression levels of SIRT6 and NMNAT2 in diabetic retinopathy (DR).Methods: We obtained peripheral blood mononuclear cells (......

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