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More than a drug target: Purinergic signalling as a source for diagnostic tools in epilepsy

期刊: NEUROPHARMACOLOGY, 2023; 222 ()

Epilepsy is one of the most common and disabling chronic neurological diseases affecting people of all ages. Major challenges of epilepsy management i......

Impact of prenatal amoxicillin exposure on hippocampal development deficiency

期刊: NEUROPHARMACOLOGY, 2023; 223 ()

Background: Amoxicillin has been widely used to treat infectious diseases during pregnancy. Current studies suggest that amoxicillin exposure during p......

The mammalian purine salvage pathway as an exploitable route for cerebral bioenergetic support after brain injury

期刊: NEUROPHARMACOLOGY, 2023; 224 ()

Purine-based molecules play ancient, fundamental, and evolutionarily-conserved roles across life on Earth, ranging from DNA and RNA, to the universal ......

Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model

期刊: NEUROPHARMACOLOGY, 2023; 233 ()

Gonadotropin-releasing hormone (GnRH) is at the head of the neuroendocrine reproductive axis. However, the non-reproductive functions of GnRH expresse......

Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/ 2-mediated BDNF synthesis in the hippocampus

期刊: NEUROPHARMACOLOGY, 2023; 240 ()

We recently reported that reversing the chronic stress-induced decline of microglia in the dentate gyrus (DG) of the hippocampus by intraperitoneal in......

Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

期刊: NEUROPHARMACOLOGY, 2023; 240 ()

Post-traumatic stress disorder (PTSD) is a complex mental disorder, closely associated with stress and traumatic events. Salidroside (Sal) has been re......

(2R,6R)-hydroxynorketamine targeting the basolateral amygdala regulates fear memory

期刊: NEUROPHARMACOLOGY, 2023; 225 ()

(2R,6R)-Hydroxynorketamine (HNK), a ketamine metabolite, has been proposed as an ideal next-generation antidepressant due to its rapid-acting and long......

Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective

期刊: NEUROPHARMACOLOGY, 2023; 234 ()

Neurosteroids are steroids synthesized de novo in the brain from cholesterol in an independent manner from peripheral steroid sources. The term neuroa......

Tetrandrine attenuates SNI-induced mechanical allodynia by inhibiting spinal CKLF1

期刊: NEUROPHARMACOLOGY, 2023; 238 ()

Neuropathic pain (NP) is a prevalent clinical problem for which satisfactory treatment options are unavailable. Tetrandrine (TET), a bisbenzylisoquino......

Inhibition of anandamide breakdown reduces pain and restores LTP and monoamine levels in the rat hippocampus via the CB1 receptor following osteoarthritis

期刊: NEUROPHARMACOLOGY, 2023; 222 ()

Chronic pain is a persistent, complex condition that contributes to impaired mood, anxiety and emotional problems. Osteoarthritis (OA) is one of the m......

Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats

期刊: NEUROPHARMACOLOGY, 2023; 227 ()

Recent studies have revealed impairments in Cacna1c +/- heterozygous animals (a gene that encodes the Cav 1.2 L-type voltage-gated calcium channels an......

PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation

期刊: NEUROPHARMACOLOGY, 2023; 235 ()

Reactive astrocytes play a potential regulatory role in sleep deprivation (SD). Paired immunoglobulin-like re-ceptor B (PirB) is expressed in reactive......

Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1aWT/A1783V mice, a preclinical model of Dravet syndrome

期刊: NEUROPHARMACOLOGY, 2023; 237 ()

Cannabidiol (CBD) has been recently approved as an antiseizure agent in Dravet Syndrome (DS), a pediatric epileptic encephalopathy, but CBD could also......

Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism

期刊: NEUROPHARMACOLOGY, 2023; 238 ()

The involvement of the mGlu5 receptors in the pathophysiology of several forms of monogenic autism has been supported by numerous studies following th......

Role of mTOR1 signaling in the antidepressant effects of ketamine and the potential of mTORC1 activators as novel antidepressants

期刊: NEUROPHARMACOLOGY, 2023; 223 ()

Conventional antidepressant medications act on monoaminergic systems and have important limitations, including a therapeutic delay of weeks to months ......

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