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Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

期刊: ONCOLOGY RESEARCH, 2023; 31 (2)

This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase (SHP-2) on the functions of tyrosine kinase rec......

Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2

期刊: ONCOLOGY RESEARCH, 2023; 31 (3)

Background: Cholangiocarcinoma (CCA) represents the epithelial cell cancer with high aggressiveness whose five-year survival rate is poor with standar......

Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis

期刊: ONCOLOGY RESEARCH, 2023; 31 (6)

Hepatocellular carcinoma (HCC) is the leading cause of cancer death worldwide; nevertheless, current therapeutic options are limited or ineffective fo......

The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma

期刊: ONCOLOGY RESEARCH, 2023; 31 (6)

Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherap......

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

期刊: ONCOLOGY RESEARCH, 2023; 31 (6)

Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatme......

Identification and verification of aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma

期刊: ONCOLOGY RESEARCH, 2023; 31 (1)

Aging is highly associated with tumor formation and progression. However, little research has explored the association of aging-related lncRNAs (ARLs)......

LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral

期刊: ONCOLOGY RESEARCH, 2023; 31 (4)

Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently, Laminin Gamma 2 (LAMC2) has been shown to be abnormally express......

YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells

期刊: ONCOLOGY RESEARCH, 2023; 31 (4)

Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It is involved in the prol......

Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study

期刊: ONCOLOGY RESEARCH, 2023; 31 (3)

The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma (CEC) patients who underwent defin......

Apolipoprotein C1 promotes tumor progression in gastric cancer

期刊: ONCOLOGY RESEARCH, 2023; 31 (3)

Background: Gastric cancer (GC) is a malignancy with the worst prognosis that seriously threatens human health, especially in East Asia. Apolipoprotei......

Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma

期刊: ONCOLOGY RESEARCH, 2023; 31 (3)

As a common tumor of the urinary system, the morbidity and mortality related to renal carcinoma, are increasing annually. Clear cell renal cell carcin......

High expression of PD-L1 mainly occurs in non-small cell lung cancer patients with squamous cell carcinoma or poor differentiation

期刊: ONCOLOGY RESEARCH, 2023; 31 (3)

Background: Lung cancer is one of the most lethal cancers worldwide, but studies have shown that the higher the expression of programmed cell death pr......

COVID-19 vaccine related hypermetabolic lymph nodes on PET/CT: Implications of inflammatory findings in cancer imaging

期刊: ONCOLOGY RESEARCH, 2023; 31 (2)

We observed several patients presenting 2-[18F]FDG uptake in the reactive axillary lymph node at PET/CT imaging, ipsilateral to the site of the COVID-......

Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-?B/p65 activation in cutaneous squamous cell carcinoma

期刊: ONCOLOGY RESEARCH, 2023; 31 (1)

Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most common malignancy worldwide. Thioredoxin (TXN) domain......

Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells

期刊: ONCOLOGY RESEARCH, 2023; 31 (1)

Small cell lung cancer (SCLC) is frequently disseminated and has a dismal prognosis with survival times of approximately two years. This cancer respon......

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