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Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses

期刊: PEDIATRIC DRUGS, 2023; 25 (3)

BackgroundThe prescription of antidepressant drugs during pregnancy has been steadily increasing for several decades. Meta-analyses (MAs), which incre......

Characterization of Cardiac Function by Echocardiographic Global Longitudinal Strain in a Cohort of Children with Neurofibromatosis Type 1 Treated with Selumetinib

期刊: PEDIATRIC DRUGS, 2023; 25 (2)

Background:Plexiform neurofibromas are benign neoplasms that develop in 20-50% children with neurofibromatosis type 1 (NF1). Selumetinib was approved ......

Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents

期刊: PEDIATRIC DRUGS, 2023; 25 (4)

Ewing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a ......

Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors

期刊: PEDIATRIC DRUGS, 2023; 25 (6)

The number of childhood cancer survivors is increasing rapidly. According to American Association for Cancer Research, there are more than 750,000 chi......

Adverse Drug Reactions in Children: Comparison of Reports Collected in a Pharmacovigilance Project Versus Spontaneously Collected ADR Reports

期刊: PEDIATRIC DRUGS, 2023; 25 (2)

Background Adverse drug reactions (ADRs) and medication errors in children may result from a lack of appropriate drugs, dosages, and pharmaceutical fo......

Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit

期刊: PEDIATRIC DRUGS, 2023; 25 (6)

IntroductionDexmedetomidine (DEX) is frequently used as an adjunct agent for prolonged sedation in the intensive care unit (ICU), though its effect on......

A Review of Histamine-2 Receptor Antagonist and Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease in Neonates and Infants

期刊: PEDIATRIC DRUGS, 2023; 25 (5)

Proton pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA) are commonly used medications in neonates and infants for the treatment of ga......

Pharmacogenetic Aspects of Drug Metabolizing Enzymes and Transporters in Pediatric Medicine: Study Progress, Clinical Practice and Future Perspectives

期刊: PEDIATRIC DRUGS, 2023; 25 (3)

As the activity of certain drug metabolizing enzymes or transporter proteins can vary with age, the effect of ontogenetic and genetic variation on the......

An Update of Pharmacological Management in Children with Functional Constipation

期刊: PEDIATRIC DRUGS, 2023; 25 (3)

Functional constipation is a common problem in childhood worldwide and has a great impact on social, physical, and emotional functioning of affected c......

Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants

期刊: PEDIATRIC DRUGS, 2023; 25 (6)

Pfizer is developing a bivalent respiratory syncytial virus (RSV) prefusion F subunit vaccine (RSVpreF; ABRYSVO (TM)) for preventing RSV illness in in......

Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review

期刊: PEDIATRIC DRUGS, 2023; 25 (1)

In recent years, there has been increased interest in using gabapentinoids (gabapentin and pregabalin) as part of multimodal medication plans or enhan......

Treatment Options in Pediatric Behcet's Disease

期刊: PEDIATRIC DRUGS, 2023; 25 (2)

Behcet's disease is a rare and poorly understood vasculitis affecting blood vessels of all types and sizes. Uveitis and oral and genital ulcers repres......

Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma

期刊: PEDIATRIC DRUGS, 2023; 25 (3)

Obesity-related asthma is associated with a high disease burden and a poor response to existent asthma therapies, suggesting that it is a distinct ast......

Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates

期刊: PEDIATRIC DRUGS, 2023; 25 (3)

Background and ObjectiveAmikacin is preferred in treating Gram-negative infections in neonates and it has a narrow therapeutic window. The population ......

Dual-Targeted Therapy in Pediatric Inflammatory Bowel Disease: A Comprehensive Review

期刊: PEDIATRIC DRUGS, 2023; 25 (5)

Inflammatory bowel disease (IBD) is a chronic systemic immune-mediated disorder. The disease is triggered and perpetuated by a complex interplay betwe......

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