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Systems genetics analysis defines importance of TMEM43/LUMA for cardiac-and metabolic-related pathways

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (1)

Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated ......

JIF:2.912

Estradiol-dependent gene expression profile in the amygdala of young ovariectomized spontaneously hypertensive rats

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (3)

Estrogen plays a role in cardiovascular functions, emotional health, and energy homeostasis via estrogen receptors expressed in the brain. The comorbi......

JIF:2.912

KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (7)

Ion channels are potentially exploitable as pharmacological targets to treat asthma. This study evaluated the role of KCa3.1 channels, encoded by Kcnn......

JIF:2.912

The influence of nutrients on mechanical overload-induced changes to skeletal muscle mRNA content

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (9)

Mechanical overload and nutrients influence skeletal muscle phenotype, with the combination sometimes having a synergistic effect. Muscle phenotypes i......

JIF:2.912

Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (9)

Extracellular vesicles (EVs) are established mediators of adaptation to exercise. Currently, there are no published data comparing changes in EVs betw......

JIF:2.912

Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (11)

Protein phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscl......

JIF:2.912

Nutrient composition influences the gut microbiota in chronic thoracic spinal cord-injured rats

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (10)

Chronic spinal cord injury (SCI) results in an increased predisposition to various metabolic problems that can be exacerbated by con-suming a diet ric......

JIF:2.912

Integrated analysis of transcriptome profiling of lncRNAs and mRNAs in livers of type 2 diabetes mellitus

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (2)

Long noncoding RNAs (lncRNAs) influence the progression of almost all human diseases, but the participation of lncRNAs in type 2 diabetes mellitus (T2......

JIF:2.912

Changes in adipose tissue microRNA expression across the menstrual cycle in regularly menstruating females: a pilot study

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (1)

Cyclical changes in hormone profiles across the menstrual cycle are associated with alterations in metabolic control. MicroRNAs (miRNAs) contribute to......

JIF:2.912

Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (5)

Atherosclerosis in the carotid artery is a major cause of ischemic stroke and has a strong genetic component. The aim of this study was to identify ge......

JIF:2.912

Single-cell RNA sequencing of mouse left ventricle reveals cellular diversity and intercommunication

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (1)

Previous studies have revealed the diversity of the whole cardiac cellulome but not refined the left ventricle, which was essential for finding therap......

JIF:2.912

Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (1)

People living with HIV (PLWH) have increased prevalence of comorbid conditions including insulin resistance and at-risk alcohol use. Circulating micro......

JIF:2.912

Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (2)

Recent studies have identified at least 20 different kidney cell types based upon chromatin structure and gene expression. Histone deacetylases (HDACs......

JIF:2.912

miR155 deficiency reduces breast tumor burden in the MMTV-PyMT mouse model

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (11)

miRNA155 (miR155) has emerged as an important regulator of breast cancer (BrCa) development. Studies have consistently noted an increase in miR155 lev......

JIF:2.912

Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise

期刊: PHYSIOLOGICAL GENOMICS, 2022; 54 (4)

microRNAs (miRs) are involved in different steps in the development of atherosclerosis and are proposed as promising biomarkers of coronary artery dis......

JIF:2.912

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