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Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 105 ()

The molecular mechanisms leading to infantile epileptic spasm syndrome (IESS) remain obscure. The only common factor seems to be that the spasms are r......

Adaptive behaviour in children exposed to topiramate in the womb: An observational cohort study

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 105 ()

Objective: Many women with epilepsy need to continue anti-seizure medications (ASMs) throughout pregnancy. The current study investigated adaptive beh......

Status epilepticus and benzodiazepine treatment: Use, underdosing and outcome-insights from a retrospective, multicentre registry

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 107 ()

Objective: To explore the reasons for and outcomes of non- or undertreatment with benzodiazepines (BZDs) in status epilepticus (SE). Methods: We retro......

Epilepsy and stigma in Africa: Viewpoint of healthcare professionals and combat strategies

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 107 ()

Epilepsy is a major public health problem in developing countries where eighty percent (80%) of people with epilepsy (PWE) live. Stigma has psychologi......

Mortality among persons with epilepsy in onchocerciasis-endemic and non-endemic areas of sub-Saharan Africa: A systematic review and meta-analysis

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Purpose: To document epilepsy-related mortality in sub-Saharan Africa (SSA) and investigate possible associations with onchocerciasis endemicity. Meth......

Safety profile of subdural and depth electrode implantations in invasive EEG exploration of drug-resistant focal epilepsy

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Purpose: To analyze the safety profile of subdural and depth electrode implantation in a large monocentric cohort of patients of all ages undergoing i......

Early predictors of remission in children and adolescents with new-onset epilepsy: A prospective study

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Purpose: This study aims to identify predictive factors of a two-year remission (2YR) in a cohort of children and adolescents with new-onset seizures ......

Novel variants in established epilepsy genes in focal epilepsy

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Introduction: Next generation sequencing (NGS) has greatly expanded our understanding of genetic contributors in multiple epilepsy syndromes, includin......

Ipsilateral preictal alpha rhythm attenuation (IPARA): An EEG sign of side of seizure onset in temporal lobe epilepsy

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Purpose: Identification of the seizure onset zone is critically important for outlining the surgical plan in the treatment of pharmacoresistant focal ......

Vagus nerve stimulation in refractory idiopathic generalised epilepsy: An Irish retrospective observational study

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 112 ()

Objective: Refractory idiopathic generalised epilepsy (IGE; also known as genetic generalised epilepsy) is a clinical challenge due to limited availab......

Real-world experience with cenobamate: A systematic review and meta-analysis

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 112 ()

Purpose: Despite many new ASM, the rate of patients with drug-resistant epilepsy (DRE) has not changed. Cenobamate (CNB) is a novel ASM for the treatm......

Real-world safety of Lacosamide: A pharmacovigilance study based on spontaneous reports in the FDA adverse event reporting system

期刊: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2023; 110 ()

Introduction: Lacosamide is licensed for the treatment of focal seizures in both adults and children, however there is little information available on......

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