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Applications of Volumetric Absorptive Microsampling Technique: A Systematic Critical Review

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (4)

Background:Microsampling is a technique that utilizes a very small volume of biological matrix, typically less than 50 & mu;L, for quantitatively ......

Pharmacokinetic/Pharmacodynamic Target Attainment of Tigecycline in Patients with Hepatic Impairment in a Real-World Setting

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (6)

Background:This study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of various tigecycline dosing regimens in rea......

An Optimized LC-MS/MS Method for Quantification of Sunitinib and N-Desethyl Sunitinib in Human Plasma and Its Application for Therapeutic Drug Monitoring

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (6)

Background: Sunitinib (SUN) malate is an oral, multitargeted, tyrosine kinase inhibitor approved for the treatment of metastatic renal cell carcinoma,......

Model-Informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient With Posterior Reversible Encephalopathy Syndrome

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (3)

Background:Considerable interpatient and interoccasion variability has been reported in tacrolimus pharmacokinetics (PK) in the pediatric renal transp......

Determination of Orelabrutinib in Human Plasma Using LC-MS/MS

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (5)

Background:Orelabrutinib is a second-generation Bruton tyrosine kinase inhibitor that improves the management of B-cell malignancies. The objective of......

Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (5)

Background:Meropenem is a carbapenem antibiotic often used in pediatric intensive care units due to its broad spectrum of activity. Therapeutic drug m......

Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (2)

Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabil......

Development and Evaluation of a Height-Based Tobramycin Initial Dosing Nomogram for the Treatment of Adult Cystic Fibrosis Pulmonary Exacerbations

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (2)

Tobramycin is widely used to treat pulmonary exacerbations of cystic fibrosis. Height has been previously found to be significantly more predictive of......

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (6)

Background: Routine therapeutic drug monitoring (TDM) relies heavily on measuring trough drug concentrations. Trough concentrations are affected not o......

Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (1)

Background:The general population widely uses herbal medicines, as they are regarded as effective and safe. St. John's wort, which is an effective her......

Acute Sodium Oxybate Intoxication: A Case Report and Review of the Literature

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (2)

Purpose:Despite a better safety profile than illicit gamma-hydroxybutyric acid (GHB) and other GHB analogs, sodium oxybate continues to raise serious ......

Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines

期刊: THERAPEUTIC DRUG MONITORING, 2023; 45 (3)

Background:Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints. These are difficult to predict owing to high interind......

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