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Risk factors for poorer respiratory outcomes in adolescents and young adults born preterm

期刊: THORAX, 2023; 78 (12)

RationaleThe respiratory outcomes for adult survivors of preterm birth in the postsurfactant era are wide-ranging with prognostic factors, especially ......

Endotyping, phenotyping and personalised therapy in obstructive sleep apnoea: are we there yet?

期刊: THORAX, 2023; 78 (7)

Obstructive sleep apnoea (OSA) was traditionally thought to be mainly caused by obesity and upper airway crowding, and hence OSA management was not pe......

Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review

期刊: THORAX, 2023; 78 (10)

BackgroundMetabolic alkalosis may lead to respiratory inhibition and increased need for ventilatory support or prolongation of weaning from ventilatio......

Understanding the effectiveness of different exercise training programme designs on V?O2peak in COPD: a component network meta-analysis

期刊: THORAX, 2023; 78 (10)

Pulmonary rehabilitation programmes including aerobic training improve cardiorespiratory fitness in patients with COPD, but the optimal programme desi......

Emulated trial investigating effects of multiple treatments: estimating combined effects of mucoactive nebulisers in cystic fibrosis using registry data

期刊: THORAX, 2023; 78 (10)

IntroductionPeople with cystic fibrosis (CF) are often on multiple long-term treatments, including mucoactive nebulisers. In the UK, the most common m......

Gut microbiota composition and metabolite profiling in smokers: a comparative study between emphysema and asymptomatic individuals with therapeutic implications

期刊: THORAX, 2023; 78 (11)

BackgroundDiet has a crucial role in the gut microbiota, and dysbiosis in the gut and lungs has been suggested to be associated with chronic obstructi......

Development of respiratory care guidelines for Duchenne muscular dystrophy in the UK: key recommendations for clinical practice

期刊: THORAX, 2023; ()

Significant inconsistencies in respiratory care provision for Duchenne muscular dystrophy (DMD) are reported across different specialist neuromuscular......

Airflow obstruction and small airway dysfunction following pulmonary tuberculosis: a cross-sectional survey

期刊: THORAX, 2023; 78 (3)

Objectives Pulmonary function impairment and chronic respiratory symptoms after tuberculosis are relatively common in low-income and middle-income cou......

Pleural and transpulmonary pressures to tailor protective ventilation in children

期刊: THORAX, 2023; 78 (1)

This review aims to: (1) describe the rationale of pleural (P-PL) and transpulmonary (P-L) pressure measurements in children during mechanical ventila......

Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study

期刊: THORAX, 2023; 78 (7)

Rationale Progressive lung function (LF) decline in patients with asthma contributes to worse outcomes. Asthma exacerbations are thought to contribute......

Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analyses

期刊: THORAX, 2023; 78 (8)

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is rare, poorly understood, with heterogeneous characteristics resulting in difficul......

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