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Inflammation-mediated changes in haemostatic variables of pulmonary tuberculosis patients during treatment

期刊: TUBERCULOSIS, 2023; 138 ()

Tuberculosis (TB) disease is usually marked by inflammation which is closely linked to haemostasis both in health and disease. Close monitoring of hae......

Macrophage activation highlight an important role for NER proteins in the survival, latency and multiplication of Mycobacterium tuberculosis

期刊: TUBERCULOSIS, 2023; 138 ()

Nucleotide excision repair (NER) is one of the most extensively studied DNA repair processes in both prokaryotes and eukaryotes. The NER pathway is a ......

Isoniazid-N-acylhydrazones as promising compounds for the anti-tuberculosis treatment

期刊: TUBERCULOSIS, 2023; 141 ()

Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis complex, still presents significant numbers of incidence and mortality, in addition ......

Mycobacterium abscessus infection results in decrease of oxidative metabolism of lung airways cells and relaxation of the epithelial mucosal tight junctions

期刊: TUBERCULOSIS, 2023; 138 ()

Mycobacterium abscessus complex is a group of environmental pathogens that recently have been isolated more from patients with underlying lung disease......

BCG vaccination induces enhanced humoral responses in elderly individuals

期刊: TUBERCULOSIS, 2023; 139 ()

Background: Studies have reported the beneficial effects of Bacillus Calmette Guerin (BCG) vaccination, including non-specific cross-protection agains......

Acquired drug resistance during the turnaround time for drug susceptibility testing impacts outcome of tuberculosis

期刊: TUBERCULOSIS, 2023; 140 ()

Background: The impacts of acquired resistance to first-line drugs other than rifampicin during turnaround time (TAT) for drug susceptibility testing ......

Limited sampling strategies for therapeutic drug monitoring of anti-tuberculosis medications: A systematic review of their feasibility and clinical utility

期刊: TUBERCULOSIS, 2023; 141 ()

Therapeutic drug monitoring (TDM) is recommended for medications with high inter-individual variability, narrow therapeutic index drugs, possible drug......

In vitro antimycobacterial activity and interaction profiles of diarylthiourea-copper (II) complexes with antitubercular drugs against Mycobacterium tuberculosis isolates

期刊: TUBERCULOSIS, 2023; 143 ()

The activity of several halogenated copper (II) complexes of 4-chloro-3-nitrophenylthiourea derivatives has been tested against Mycobacterium tubercul......

The PPE2 protein of Mycobacterium tuberculosis is secreted during infection and facilitates mycobacterial survival inside the host

期刊: TUBERCULOSIS, 2023; 143 ()

Mycobacterium tuberculosis secrets various effector proteins to evade host immune responses for facilitating its intracellular survival. The bacterial......

Tuberculosis in mummies - New findings, perspectives and limitations

期刊: TUBERCULOSIS, 2023; 143 ()

The molecular analysis of ancient pathogen DNA represents a unique opportunity for the study of infectious diseases in ancient human remains. Among ot......

Upper Paleolithic tuberculosis: A probable case illustrated by paleoimaging methods (Azilian site of Les Iboussieres, France)

期刊: TUBERCULOSIS, 2023; 143 ()

The aim of this paper is to present the results of mu CT-scan and 3D imaging analyses of two skeletal lesions observed on human remains of one of the ......

Genetic mutations underlying isoniazid-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan

期刊: TUBERCULOSIS, 2023; 138 ()

Tuberculosis, caused by Mycobacterium tuberculosis, is a major public health issue in Pakistan. Isoniazid is a first-line pro-drug that requires activ......

Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen

期刊: TUBERCULOSIS, 2023; 138 ()

Prophylactic efficacy of two different delivery platforms for vaccination against Mycobacterium avium (M. avium) were tested in this study; a subunit ......

A novel chemogenomic discovery platform identifies bioactive hits with rapid bactericidal activity against Mycobacteroides Abscessus

期刊: TUBERCULOSIS, 2023; 139 ()

Mycobacteroides abscessus (M. ab) infections are innately resistant to most currently available antibiotics and present a growing, poorly addressed me......

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