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Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

Merkel cell polyomavirus (MCV) and high-risk human papillomavirus (HPV) are human tumor viruses that cause Merkel cell carcinoma (MCC) and oropharynge......

Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia?

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

The International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, clinical and public health res......

Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec'2017. We investigated whether pro......

Interplay between the DNA damage response and the life cycle of DNA tumor viruses

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

Approximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in host cells by disrupting the ......

Elevated iNOS and 3?-nitrotyrosine in Kaposi?s Sarcoma tumors and mouse model

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Kaposi's Sarcoma (KS) is a heterogenous, multifocal vascular malignancy caused by the human herpesvirus 8 (HHV8), also known as Kaposi's Sarcoma-Assoc......

Characterization of HPV subtypes in invasive cervical cancer in Botswana patients using a pan-pathogen microarray technology

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Human papillomavirus (HPV) plays a significant role in the development of cervical cancers in the setting of coinfection with HIV. Botswana has a high......

Association of two genomic variants with HPV type-specific risk of cervical cancer

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

Problem: Human papillomavirus infection is integral to developing invasive cervical cancer in the majority of patients. In a recent genome-wide associ......

Construction of a diagnostic model for hepatitis B-related hepatocellular carcinoma using machine learning and artificial neural networks and revealing the correlation by immunoassay

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

HBV infection profoundly escalates hepatocellular carcinoma (HCC) susceptibility, responsible for a majority of HCC cases. HBV-driven immune-mediated ......

Unresolved issues in the management of human papillomavirus-associated mucosal high-grade pre-cancers

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

This article reviews human papillomavirus-associated mucosal high-grade pre-cancers and their management. It examines pre-cancer classification system......

Human papillomavirus genomics: Understanding carcinogenicity

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other anatomical sites in both men and women. However, only 12 of......

Identification and characterisation of novel potential phospho-acceptor sites in HPV-16 E7

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

Several studies have described functional regulation of high-risk human papillomaviruses (HPVs), E6 and E7 oncoproteins via posttranslational modifica......

Tegument proteins of Epstein-Barr virus: Diverse functions, complex networks, and oncogenesis

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

The tegument is the structure between the envelope and nucleocapsid of herpesvirus particles. Viral (and cellular) proteins accumulate to create the l......

Diversity of cervicovaginal human papillomavirus (HPV) genotypes and naturally occurring E6/E7 DNA polymorphisms of HPV-16 in Ghana

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Human papillomavirus (HPV) E6 and E7 oncogene expression is essential for cervical carcinogenesis. Evidence exists that E6/E7 variants may have differ......

Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition

期刊: TUMOUR VIRUS RESEARCH, 2023; 15 ()

Previous studies have shown that the high-risk HPV E6 oncoprotein PDZ binding motifs (PBMs) can interact with PDZ proteins or members of the 14-3-3 fa......

The human Papillomavirus twilight zone-Latency, immune control and subclinical infection

期刊: TUMOUR VIRUS RESEARCH, 2023; 16 ()

The incorporation of HPV DNA testing into cervical screening programs has shown that many HPV-positive women are cytologically normal, with HPV-positi......

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