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Prostacyclin mimetics inhibit DRP1-mediated pro-proliferative mitochondrial fragmentation in pulmonary arterial hypertension

期刊: VASCULAR PHARMACOLOGY, 2023; 151 ()

Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder, involving the remodelling of the small pulmonary arteries. Underlying this r......

Pathophysiology of coronary microvascular dysfunction

期刊: VASCULAR PHARMACOLOGY, 2023; 153 ()

The term coronary microvascular dysfunction (CMD) encompasses several pathogenetic mechanisms resulting in functional and/or structural changes in the......

Sodium nitroprusside for advanced heart failure. A metanalysis of literature data

期刊: VASCULAR PHARMACOLOGY, 2023; 148 ()

Advanced heart failure (HF) is associated with a very poor prognosis and places a big burden on health-care services. The gold standard treatment, i.e......

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice

期刊: VASCULAR PHARMACOLOGY, 2023; 150 ()

Background and purpose: Pregnancy-associated vascular remodelling is essential for both maternal and fetal health. We have previously shown that mater......

The impacts of endogenous progesterone and exogenous progestin on vascular endothelial cell, and smooth muscle cell function: A narrative review

期刊: VASCULAR PHARMACOLOGY, 2023; 152 ()

Vascular endothelial and smooth muscle cell dysfunction proceed the development of numerous vascular diseases, such as atherosclerosis. Both estrogen ......

Hypertension, coronary artery disease and myocardial ischemic syndromes

期刊: VASCULAR PHARMACOLOGY, 2023; 153 ()

Hypertension represents a major contributor to the development of coronary artery disease. The pathophysiological mechanisms underlying the link betwe......

Amyloid-β: A potential mediator of aging-related vascular pathologies

期刊: VASCULAR PHARMACOLOGY, 2023; 152 ()

Aging is one of the most promising risk factors for vascular diseases, however, the precise mechanisms mediating aging-related pathologies are not ful......

Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention

期刊: VASCULAR PHARMACOLOGY, 2023; 153 ()

Inflammation and hyperlipidemia act synergistically to drive atherosclerotic progression. Multiple randomized trials now demonstrate that lower is bet......

Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction

期刊: VASCULAR PHARMACOLOGY, 2023; 150 ()

Aims: The prevalence of left ventricular (LV) diastolic and vascular dysfunction increases with age, eventually leading to heart failure with preserve......

The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets

期刊: VASCULAR PHARMACOLOGY, 2023; 151 ()

Pulmonary hypertension due to left heart disease (PH-LHD) or group 2 PH is the most common and lethal form of PH, occurring secondary to left ventricu......

Prolonged impact of anti-cancer therapy on endothelial function and arterial stiffness in breast cancer patients

期刊: VASCULAR PHARMACOLOGY, 2023; 152 ()

Background: Cardiotoxicity restricts anthracycline and trastuzumab treatment of Human Epidermal Growth Factor Receptor 2 positive early breast cancer.......

Heterogeneous vasomotor responses in segments from Gottingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study

期刊: VASCULAR PHARMACOLOGY, 2023; 153 ()

Gottingen Minipigs (GM) are used as an important preclinical model for cardiovascular safety pharmacology and for evaluation of cardiovascular drug ta......

Involvement of HIF1α/Reg protein in the regulation of HMGB3 in myocardial infarction

期刊: VASCULAR PHARMACOLOGY, 2023; 152 ()

Aims: Myocardial ischemia and infarction are the number one cause of cardiovascular disease associated mortality. Cardiomyocyte death during ischemia ......

Long-acting opioids and cardiovascular diseases: Help or hindrance!

期刊: VASCULAR PHARMACOLOGY, 2023; 149 ()

Opioids are widely being used for chronic pain management, cough and diarrhea suppressants, anesthetic agents, and opioid de-addiction therapy. Opioid......

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