期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (661)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus driving the ongoing coronavirus disease 2019 (COVID-19) pandemic, continues to......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (653)
Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin. Although scratching transiently relieves acute itch through......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (654)
Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing the potential risk associated with permanent genetic c......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (656)
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patien......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (664)
Chronic pancreatitis (CP) is characterized by progressive fibrosis and exocrine dysregulation, which have long been considered irreversible. As a peri......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (629)
Leukemia stem cells (LSCs) propagate leukemia and are responsible for the high frequency of relapse of treated patients. The ability to target LSCs re......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (630)
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and ......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (626)
High CD8(+) T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and a satisfactory response to immunotherapy; however,......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (656)
Diabetes is a major public health issue because of its widely epidemic nature and lack of cure. Here, we show that pancreas-derived mesenchymal stem c......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (648)
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, th......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (639)
Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely el......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (648)
Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden death in high-incidence areas. SCN5A encodes cardiac sodium cha......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (669)
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we repo......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (673)
Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in patients with cancer that can lead to impaired therapeutic outcome and surviva......
期刊: SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (659)
Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of......