期刊： DRUG DISCOVERY TODAY, 2021; 26 (3)
Cancer cells metabolize glucose via anaerobic glycolysis, with lactate formed in the cytosol as the end-product. To avoid intercellular acidification,......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (7)
Solute carrier (SLC) transporters are primarily known for their function in the transportation of various exogenous/endogenous substances via influx/e......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (7)
Triple-negative breast cancers (TNBCs) form a heterogeneous group of breast carcinomas that lack expression of estrogen receptor, progesterone recepto......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (6)
The placenta has vital roles in metabolite exchange, fetal growth, and preeclampsia (PE). In this review, we discuss the pathogenesis of hypertension ......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (5)
Reactive oxygen species (ROS) have emerged as key players in regulating the fate and function of stem cells from both non-hematopoietic and hematopoie......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (8)
Cancer-on-a-chip has recently emerged and attracted wide attention in the field of anticancer drug screening. Compared with traditional cancer models,......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (4)
Stroke ranks as the second leading cause of death across the globe. Despite advances in stroke therapeutics, no US Food and Drug Administration (FDA)-......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (6)
In 2010, the pan-assay interference compounds (PAINS) rule was proposed to identify false-positive compounds, especially frequent hitters (FHs), in bi......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (6)
The goal of de novo drug design is to create novel chemical entities with desired biological activities and pharmacokinetics (PK) properties. Over rec......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (6)
Innate immunity serves as a first line of defence against danger signals, invading pathogens and microbes. The inflammasomes, as pattern recognition r......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (2)
Gene therapy involves the introduction of new genes into cells, to modify or manipulate the expression of a gene or to alter the biological properties......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (8)
Photothermal therapy (PTT) has emerged as a promising therapeutic approach for tumor control and ablation. Attention has focused on exploring advanced......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (4)
Urokinase-type plasminogen activator receptor (uPAR) mediates a multitude of biological activities, has key roles in several clinical indications, inc......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (4)
Human caseinolytic protease P (HsClpP), an ATP-dependent unfolding peptidase protein in the mitochondrial matrix, controls protein quality, regulates ......
期刊： DRUG DISCOVERY TODAY, 2021; 26 (6)
Obesity is positively correlated with a variety of metabolic disorders. Autophagy is the major recycling process in adipocytes, dynamically regulating......
