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Construction and Analysis of mRNA and lncRNA Regulatory Networks Reveal the Key Genes Associated with Prostate Cancer Related Fatigue During Localized Radiation Therapy

期刊: CURRENT BIOINFORMATICS, 2021; 16 (2)

Background: Localized radiation therapy is the first-line option for the treatment of nonmetastatic prostate cancer (PCa). Previous studies revealed t......

Prediction of Microbe-drug Associations Based on Chemical Structures and the KATZ Measure

期刊: CURRENT BIOINFORMATICS, 2021; 16 (6)

Background: Microbial communities have important influences on our health and disease. Identifying potential human microbe-drug associations will be g......

Chemical Genetic Validation of GWAS-derived Disease Loci

期刊: CURRENT BIOINFORMATICS, 2021; 16 (6)

Background: Genome-wide association studies (GWAS) have opened the door to unprecedented large-scale identification of susceptibility loci for human d......

Quantum Patterns of Genome Size Variation in Angiosperms

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Aims: The discontinuous pattern of genome size variation in angiosperms is an unsolved problem related to genome evolution. In this study, we introduc......

An Efficient Multiple Kernel Support Vector Regression Model for Assessing Dry Weight of Hemodialysis Patients

期刊: CURRENT BIOINFORMATICS, 2021; 16 (2)

Background: Dry Weight (DW) is the lowest weight after dialysis, and patients with lower weight usually have symptoms of hypotension and shock. Severa......

Identification of Genomic Islands in Synechococcus sp. WH8102 Using Genomic Barcode and Whole-genome Microarray Analysis

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Background: Synechococcus sp. WH8102 is one of the most abundant photosynthetic organisms in many ocean regions. Objective: The aim of this study is t......

A Novel Hybrid Filter/Wrapper Feature Selection Approach Based on Improved Fruit Fly Optimization Algorithm and Chi-square Test for High Dimensional Microarray Data

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Microarray data is widely utilized for disease analysis and diagnosis. However, it is hard to process them directly and achieve high classification ac......

Comprehensive Analysis Reveals GPRIN1 is a Potential Biomarker for Non-small Cell Lung Cancer

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Background: Non-small cell lung cancer (NSCLC) is one of the most leading cause of tumor related mortality worldwide. However, the prognosis of NSCLC ......

Distinguishing Enzymes and Non-enzymes Based on Structural Information with an Alignment Free Approach

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Background: Knowledge of protein functions is very crucial for the understanding of biological processes. Experimental methods for protein function pr......

Bioinformatics Analysis Reveals Centromere Protein K can Serve as Potential Prognostic Biomarker and Therapeutic Target for Non-small Cell Lung Cancer

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Background: Non-small cell lung carcinoma (NSCLC) accounts for 80% of all lung cancer cases, which have been a leading cause of morbidity and mortalit......

Effective Classification of Melting Curve in Real-time PCR Based on Dynamic Filter-based Convolutional Neural Network

期刊: CURRENT BIOINFORMATICS, 2021; 16 (6)

Background: The effective classification of the melting curve is conducive to measure the specificity of the amplified products and the influence of i......

A Network Pharmacology Approach to Explore the Underlying Mecha-nism of Tufuling Qiwei Tangsan in Treating Psoriasis

期刊: CURRENT BIOINFORMATICS, 2021; 16 (6)

Background: Tufuling Qiwei Tangsan (TQTS) is a commonly used Mongolian medicine preparation against psoriasis in China. However, its mechanism of acti......

Identification of KEY lncRNAs and mRNAs Associated with Oral Squamous Cell Carcinoma Progression

期刊: CURRENT BIOINFORMATICS, 2021; 16 (2)

Background: Oral squamous cell carcinoma (OSCC) has been the sixth most common cancer worldwide. Emerging studies showed long non-coding RNAs to play ......

Identification of Critical Functional Modules and Signaling Pathways in Osteoporosis

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Background: Osteoporosis is the most common bone metabolic disease. Abnormal osteoclast formation and resorption play a fundamental role in osteoporos......

Identification of Glioma Specific Genes as Diagnostic and Prognostic Markers for Glioma

期刊: CURRENT BIOINFORMATICS, 2021; 16 (1)

Malignant gliomas are the most prevalent malignancy of the brain. However, there is still a lack of sensitive and accurate biomarkers for gliomas. In ......

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