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Anti-gastric cancer activity and mechanism of natural compound "Heilaohulignan C" isolated from Kadsura coccinea

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (7)

In this research, we analyzed the antitumor activity of one new compound Heilaohulignan C (B-6) on the human gastric carcinoma cells. MTT, cell migrat......

Protection by ginseng saponins against cyclophosphamide-induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l-arginine/nitric oxide pathway based on metabolomics

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (6)

Ginseng saponins (GS) are the main active compounds in Panax ginseng and have been proven to be highly effective in attenuating the side effects of ch......

Rotundic acid reduces LPS-induced acute lung injury in vitro and in vivo through regulating TLR4 dimer

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Acute lung injury (ALI) is a serious clinical disease. Rotundic acid (RA), a natural ingredient isolated from Ilex rotunda Thunb, exhibits multiple ph......

Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K-Akt-mTOR signaling pathway

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (3)

Daturataturin A (DTA), a withanolide compound in Datura metel L., exhibits excellent anti-inflammatory and anti-proliferative activities. Here, we rep......

Scutellarin ameliorates the stress-induced anxiety-like behaviors in mice by regulating neurotransmitters

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (7)

Anxiety disorders are a common frequently psychiatric symptom in patients that lead to disruption of daily life. Scutellarin (Scu) is the main compone......

Cucurbitacin IIa: A review of phytochemistry and pharmacology

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Cucurbitacin IIa was first found in plants and it belongs to tetracyclo triterpenoids. It is one of the most important active components in cucurbitac......

Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Oxidative stress plays the main role in the pathogenesis of diabetes mellitus and peripheral neuropathy. Polydatin (PD) has been shown to exhibit stro......

Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Cisplatin (DDP) is widely used in cancer treatment, but DDP can cause skeletal muscle atrophy and cachexia. This study explored the effect and mechani......

Activation of autophagy contributes to the protective effects of lycopene against oxidative stress-induced apoptosis in rat chondrocytes

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (7)

Oxidative stress is commonly associated with osteoarthritis (OA). Lycopene (LYC), a natural carotenoid compound, is an effective antioxidant with pote......

Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Regorafenib (RGF), a second-line multi-kinase inhibitor in the treatment of HCC (hepatocellular carcinoma) after sorafenib failure, exposes to the ris......

Moschamindole induces glioma cell apoptosis by blocking Mia40-dependent mitochondrial intermembrane space assembly and oxidative respiration

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (6)

Glioblastoma multiforme (GBM) is the most frequent, lethal, and aggressive tumor of the central nervous system in adults. In this study, we found for ......

Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Erycibes are members of the Convolvulaceae family, including more than 10 species worldwide that are distributed in tropical Asia. Some Erycibes speci......

The p53/p21/p16 and PI3K/Akt signaling pathways are involved in the ameliorative effects of maltol on D-galactose-induced liver and kidney aging and injury

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

Successive evidence has established that maltol, a flavor-enhancing agent, could provide resistance to oxidative stress-induced tissue injury in vario......

Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (8)

The VEGF/SphK1/S1P pathway is closely related to angiogenesis in rheumatoid arthritis (RA), but the precise underlying mechanisms are unclear at prese......

Sarsasapogenin ameliorates diabetes-associated memory impairment and neuroinflammation through down-regulation of PAR-1 receptor

期刊: PHYTOTHERAPY RESEARCH, 2021; 35 (6)

Sarsasapogenin (Sar), a natural steroidal compound, shows neuroprotection, cognition-enhancement, antiinflammation, antithrombosis effects, and so on.......

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