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Plasma Exosomes in Inherited Forms of Parkinson's Disease

期刊: MOLECULAR BIOLOGY, 2021; 55 (2)

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha-synuclein misfolding and aggregation resulting in neurototoxicity......

Mesenchymal Stem Cells Cultured in 3D System Inhibit Non-Small Cell Lung Cancer Cells through p38 MAPK and CXCR4/AKT Pathways by IL-24 Regulating

期刊: MOLECULAR BIOLOGY, 2021; 55 (4)

Non-small cell lung cancer (NSCLC) is prevalent worldwide and has a high mortality rate. Even if mesenchymal stem cells (MSCs) are suggested as cancer......

Protein Disulfide Bonds Detected by Tagging with High Molecular Weight Maleimide Derivative

期刊: MOLECULAR BIOLOGY, ; ()

Disulfide bridges are essential for maintaining the structure and function of proteins. Traditionally, studies of the disulfide bonds require expensiv......

The Expression of Genes Encoding ABCA1 and ABCG1 Transporters and PPAR gamma, LXR beta, and ROR alpha Transcriptional Factors in Subcutaneous and Visceral Adipose Tissue in Women with Metabolic Syndrome

期刊: MOLECULAR BIOLOGY, 2021; 55 (1)

The study aimed to investigate tissue-specific gene expression of ABCA1 and ABCG1, encoding cholesterol transporters, as well as PPARG, LXR beta (NR1H......

Levels of sgRNA as a Major Factor Affecting CRISPRi Knockdown Efficiency in K562 Cells

期刊: MOLECULAR BIOLOGY, 2021; 55 (1)

To determine how nuclease deactivated Cas9 (dCas9) or single-guide RNA (sgRNA) expression levels affect the knockdown efficiency of CRISPRi, we create......

The pH-Sensitive Potassium Channel TASK-1 Is a Chemosensor for Central Respiratory Regulation in Rats

期刊: MOLECULAR BIOLOGY, 2020; 54 (3)

TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a "leak" potassium channel sensitive to extracellular protons. It contributes to setting t......

Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish

期刊: MOLECULAR BIOLOGY, 2020; 54 (3)

Homology-directed (HD) genome modification offers an opportunity to precisely modify the genome. Despite reported successful cases, for many loci, pre......

Functional Characterization of ZmHAK1 Promoter and Its Regulatory Transcription Factors in Maize

期刊: MOLECULAR BIOLOGY, 2020; 54 (3)

Potassium (K+) deficiency in the soil may seriously affect the yield and quality of plants, which usually satisfy their potassium requirements by enga......

CbCYP716A261, a New beta-Amyrin 28-Hydroxylase Involved in Conyzasaponin Biosynthesis from Conyza blinii

期刊: MOLECULAR BIOLOGY, 2020; 54 (5)

Conyzasaponins produced by the traditional Chinese herbConyza bliniiare oleanane-type saponins with a wide range of biological activities. Here, we id......

Identification and Characterization of circRNAs in the Developing Stem Cambium of Poplar Seedlings

期刊: MOLECULAR BIOLOGY, 2020; 54 (5)

Non-coding RNAs are a class of RNAs with multiple roles in plant life. Covalently closed circular RNA molecules (circRNAs) have been recently shown to......

Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells

期刊: MOLECULAR BIOLOGY, 2022; 56 (5)

Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis......

JIF:0.759

Extraction and Separation of Sinapine from Rapeseed Cake and the Mode of Action of Melanin Production Inhibition

期刊: MOLECULAR BIOLOGY, 2020; 54 (6)

Abstract- Brassica campestris L. is the important oil-bearing crop in China. Rapeseed cake is the main byproduct of rapeseed oil extraction. As the ma......

shRNA-Mediated Suppression of gamma-Synuclein Leading to Downregulation of p38/ERK/JNK Phosphorylation and Cell Cycle Arrest in Endometrial Cancer Cells

期刊: MOLECULAR BIOLOGY, 2020; 54 (6)

In this study, we explored the effects of treating human endometrial cancer cells with gamma-synuclein-specific short hairpin RNA (shRNA) and elucidat......

A Qualitative Proteome-Wide Lysine Succinylation Profiling of Tea Revealed its Involvement in Primary Metabolism

期刊: MOLECULAR BIOLOGY, 2020; 54 (1)

Lysine succinylation of proteins has potential impacts on protein structure and function, which occurs on post-translation level. However, the informa......

miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC

期刊: MOLECULAR BIOLOGY, 2020; 54 (1)

Hepatocellular carcinoma (HCC) is a common malignancy worldwide with poor prognosis and high mortality. The aberrant expression or alteration of micro......

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