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Pyoluteorin Induces Apoptosis and Autophagy in NSCLC Cells

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (7)

Pyoluteorin is a natural occurring antibiotic and its anti-tumor activity has rarely been reported. This study aims to investigate the anti-tumor effe......

Propofol Affects EGF's Activity in Intestinal Cell by Down-Regulating EGFR-Mediated Intracellular Signaling

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (7)

Propofol is a commonly used anesthetic drug in clinic. In recent years, a series of non-anesthetic effects of propofol have been discovered. Studies h......

Emodin Suppresses the Migration and Invasion of Melanoma Cells

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (6)

Emodin (1,3,8-trihydroxy-6-methylanthraquinone), as an active ingredient in rhubarb roots and rhizomes, has been reported to possess various pharmacol......

Electrophysiological Response to Acehytisine Was Modulated by Aldosterone in Rats with Aorto-Venocaval Shunts

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (8)

Aldosterone induces cardiac electrical and structural remodeling, which leads to the development of heart failure and/or atrial fibrillation (AF). How......

Low Expression of Rasal2 Promotes Non-small Cell Lung Cancer Metastasis through Ras/ERK Pathway

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (7)

The RAS protein activator like 2 (Rasal2) has been reported to be a tumor suppressor in variety of cancers; while an oncogenic protein in ovarian canc......

Anti-inflammatory Effects of Sanhuang-Siwu-Tang in Lipopolysaccharide-Stimulated RAW264.7 Macrophages and BV2 Microglial Cells

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (4)

Sanhuang-Siwu-Tang (SST), composed of seven medicinal herbs, is a well-known herbal formula used for the treatment of gynecologic diseases. To expand ......

Overexpressed Hsa_circ_0001326 Contributes to the Decreased Cell Viability in SWAN71 Cells by Regulating MiR-186-5p/p27 Kip1 Axis

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (4)

Preeclampsia (PE) is a severe pregnancy-specific complication responsible for a majority of maternal and fetal mortality. The dysfunction of trophobla......

Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (7)

Local anesthetic toxicity is closely related to neuronal death and activation of the inflammatory response. Dexmedetomidine (Dex) is an adrenergic alp......

Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (8)

Hydrogen sulfide (H2S), an important gaseous messenger, is known to have neuroprotective effects in many neurological disorders. This study examined t......

Macrophage Response Driven by Extracellular ATP

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (5)

The purine nucleotide ATP is a fundamental unit in cellular energy metabolism. Extracellular ATP and its metabolites are also ligands for a family of ......

Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-kappa B and Nrf2/HO-1 Pathways

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (9)

Betanin, a bioactive ingredient mostly isolated from beetroots, exhibits a protective effect against cardiovascular diseases. However, its effects on ......

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (6)

Gastric cancer is one of the most common malignancies with a high mortality rate world. This study intends to make clear the role and mechanism of the......

Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury via Suppression of Macrophage Involved Inflammation

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (5)

Ischemia reperfusion injury (IRI) is the major cause of acute kidney injury (AKI). The previous studies demonstrated that Oridonin can protect kidney ......

Pannexin 1 Mediates Gastric Cancer Cell Epithelial-Mesenchymal Transition via Aquaporin 5

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (8)

Pannexin 1 (PANX1) has been implicated in cancer emergence and progression. However, its roles in gastric cancer remain unclear. In the present study,......

4D-QSAR Molecular Modeling and Analysis of Flavonoid Derivatives as Acetylcholinesterase Inhibitors

期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021; 44 (7)

Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzhe......

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