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The role of N6-methyladenosine mRNA in the tumor microenvironment

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

In recent years, the most widely distributed eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A), has received a large amount of in......

Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

After it was discovered approximately 40 years ago, carbohydrate antigen 125 (CA125) became the most widely used and concerning biomarker in ovarian c......

Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

Cancer is a major cause of morbidity and mortality worldwide due to its ability to evade immune surveillance and metastasize from its origin to a seco......

Autophagy signals orchestrate chemoresistance of gynecological cancers

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

Gynecological cancers are characterized by a high mortality rate when chemoresistance develops. Autophagy collaborates with apoptosis and participates......

Centrosome amplification in cancer and cancer-associated human diseases

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Accumulated evidence from genetically modified cell and animal models indicates that centrosome amplification (CA) can initiate tumorigenesis with met......

The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Reversible phosphorylation of proteins, controlled by kinases and phosphatases, is involved in various cellular processes. Dual-specificity phosphatas......

DNA damage response inhibitors: An avenue for TNBC treatment

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

The DNA damage response (DDR) is critical for the maintenance of genomic stability by sensing DNA damage, regulating cell cycle and initiating DNA rep......

HER2-targeted therapies in gastric cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Molecular targeted therapy of cancer has always been the focus of clinicians. Among those therapeutic targets, the human epidermal growth factor recep......

Targeting Bcl-2 for cancer therapy

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Apoptosis deficiency is one of the most important features observed in neoplastic diseases. The Bcl-2 family is composed of a subset of proteins that ......

Mitochondria: The metabolic switch of cellular oncogenic transformation

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Mitochondria, well recognized as the "powerhouse" of cells, are maternally inherited organelles with bacterial ancestry that play essential roles in a......

Pathogenesis and therapeutic strategy in platinum resistance lung cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Platinum compounds (cisplatin and carboplatin) represent the most active anticancer agents in clinical use both of lung cancer in mono-and combination......

Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1875 (2)

Carbohydrate antigen 19-9 (CA19-9) is the best validated biomarker and an indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions a......

The interaction of SET and protein phosphatase 2A as target for cancer therapy

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

In cancer cells, tumor suppressor proteins loss-of-function are usually the result of genetic mutations. Protein Phosphatase 2A is a tumor suppressor ......

Epithelial-mesenchymal transition: When tumor cells meet myeloid-derived suppressor cells

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population characterized by pro-tumoral functions in the tumor immune networ......

Oncogenic cancer/testis antigens are a hallmarker of cancer and a sensible target for cancer immunotherapy

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021; 1876 (1)

Increasing evidence shows that numerous cancer-testis antigens (CTAs) are uniquely overexpressed in various types of cancer and most CTAs are oncogeni......

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