期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Alzheimer's disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesi......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Animal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-deriv......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Background: beta Amyloid (A beta)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer's disease (AD), is recently proposed ......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological ......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and ......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Objectives: The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Background: Accumulation of alpha-synuclein (alpha-syn) is a main pathological hallmark of Parkinson's and related diseases, which are collectively kn......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Background Blood-based test for predicting disease progression and early diagnosis of Parkinson's disease (PD) is an unmet need in the clinic. The pro......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Background Currently, there is no cure for Alzheimer's disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent st......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Objective: There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brai......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Alzheimer's disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavir......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson's disease (PD), are largely unknown, al......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Par......
期刊： TRANSLATIONAL NEURODEGENERATION, 2021; 10 (1)
PIWI-interacting RNAs (piRNAs) are small non-coding transcripts that are highly conserved across species and regulate gene expression through pre- and......
