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Quench me if you can: Alpha-2-macroglobulin trypsin complexes enable serum biomarker analysis by MALDI mass spectrometry

期刊: BIOCHIMIE, 2021; 185 ()

One of the main functions of alpha-2-macroglobulin (A2M) in human blood serum is the binding of all classes of protease. It is known that trypsin, aft......

Biochemical characterization of a unique DNA polymerase A from the extreme radioresistant organism Deinococcus radiodurans

期刊: BIOCHIMIE, 2021; 185 ()

Deinococcus radiodurans survives extraordinary doses of ionizing radiation and desiccation that cause numerous DNA strand breaks. D. radiodurans DNA p......

Role of pyroptosis in cancer cells and clinical applications

期刊: BIOCHIMIE, 2021; 185 ()

Chemotherapy drugs usually inhibit tumor cell growth through the apoptosis pathway. However, tumor cells become resistant to chemotherapy drugs by eva......

The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications

期刊: BIOCHIMIE, 2021; 184 ()

L-Valine, L-isoleucine, and L-leucine are three key proteinogenic amino acids, and they are also the essential amino acids required for mammalian grow......

Proteomics analysis of Cyclobalanopsis gilva provides new insights of low seed germination

期刊: BIOCHIMIE, 2021; 180 ()

A valuable plant, Cyclobalanopsis gilva, (C. gilva) has a low germination rate (below 50%) under its natural habitations. In order to examine the reas......

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response

期刊: BIOCHIMIE, 2021; 180 ()

Current mortality due to the Covid-19 pandemic (approximately 1.2 million by November 2020) demonstrates the lack of an effective treatment. As replic......

High salt diet contributes to hypertension by weakening the medullary tricarboxylic acid cycle and antioxidant system in Dahl salt-sensitive rats

期刊: BIOCHIMIE, 2021; 181 ()

High salt diet (HSD, 8% NaCl) contributes to salt-sensitive hypertension, this study aimed to determine the effect of HSD on salt-sensitive hypertensi......

Mesenchymal stem cells: Biological characteristics and application in disease therapy

期刊: BIOCHIMIE, 2021; 185 ()

Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for self-renewal and multipotential differentiation, MSCs also h......

Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein

期刊: BIOCHIMIE, 2021; 187 ()

The recent outbreak of SARS-CoV-2 has had a profound effect on the world. Similar to that in SARS-CoV, the entry receptor of SARS-CoV-2 is ACE2. The b......

Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKC delta protein

期刊: BIOCHIMIE, 2021; 184 ()

Acquired drug-resistance, often involving downregulation or mutations in the target protein, is a major caveat in precision medicine. Understanding me......

Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases

期刊: BIOCHIMIE, 2021; 180 ()

Regulated cell death (RCD) is a universal process in living organisms that is essential for tissue homeostasis or to the restoration of biological equ......

Isocitrate dehydrogenase 1 from Acinetobacter baummanii (AbIDH1) enzymatic characterization and its regulation by phosphorylation

期刊: BIOCHIMIE, 2021; 181 ()

Acinetobacter baumannii encodes all enzymes required in the tricarboxylic acid (TCA) cycle and glyoxylate bypass except for isocitrate dehydrogenase k......

Nuclear transformation of Chlamydomonas reinhardtii: A review

期刊: BIOCHIMIE, 2021; 181 ()

Chlamydomonas reinhardtii is a model organism with three sequenced genomes capable of genetic transformation. C. reinhardtii has the advantages of bei......

Modification of DNA regions with metagenomic DNA fragments (MDRMDF): A convenient strategy for efficient protein engineering

期刊: BIOCHIMIE, 2021; 187 ()

In this study, we have established a convenient and efficient approach named Modification of DNA Regions with Metagenomic DNA Fragments (MDRMDF) for p......

Cellular and molecular modification of egg envelope hardening in fertilization

期刊: BIOCHIMIE, 2021; 181 ()

Fertilization is an essential process that fundamentally impacts fitness. An egg changes dramatically after fertilization mediating the beginning of l......

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