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High-pressure asymmetric hydrogenation in a customized flow reactor and its application in multi-step flow synthesis of chiral drugs

期刊: JOURNAL OF FLOW CHEMISTRY, ; ()

Asymmetric homogeneous hydrogenation under high pressure in continuous flow was achieved with a slug flow reactor. High hydrogen pressure enabled irid......

Continuous nitration of o-dichlorobenzene in micropacked-bed reactor: process design and modelling

期刊: JOURNAL OF FLOW CHEMISTRY, ; ()

The matching of the micro-dispersion method and the reaction kinetics is of the utmost importance for the fast and strongly exothermic nitration react......

Hydrogenation of nitroarenes in continuous flow with TPP/Raney Ni

期刊: JOURNAL OF FLOW CHEMISTRY, ; ()

In this work, the method of combining the various ligands with Raney Ni in continuous flow is proposed, in which triphenylphosphine (TPP) can effectiv......

Continuous synthesis of monodisperse silica microspheres over 1 mu m size

期刊: JOURNAL OF FLOW CHEMISTRY, ; ()

This study presents a robust and scalable method for synthesizing continuously the silica microspheres via the Stober method. Owing to the superb mixi......

Process intensification in carbonylation of formaldehyde with active and passive enhancement methods

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (4)

The process intensification in carbonylation of formaldehyde by active and passive enhancement was investigated in stirred tank reactor and membrane c......

One-step microdevices for synthesizing morphology-controlled ultraviolet-curable polysiloxane shell particles

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (4)

Double emulsions have great potential application in many fields. Although many companies and research institutions have developed various strategies ......

Catalyst-free biphasic oxidation of Thiophenes in continuous-flow

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (4)

A mild and practical oxidation process of thiophene derivatives in continuous-flow has been developed. The oxidant phase consists ofmCPBA and acetonit......

Continuous-flow double diazotization for the synthesis ofm-difluorobenzene via Balz-Schiemann reaction

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (4)

m-Difluorobenzene is an important structural in many pharmaceutical agents and nature products. However, the conventional method of preparingm-difluor......

Manipulation of gas-liquid-liquid systems in continuous flow microreactors for efficient reaction processes

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (1)

Gas-liquid-liquid flow in microreactors holds great potential towards process intensification of operation in multiphase systems, particularly by a pr......

Organocatalyzed styrene epoxidation accelerated by continuous-flow reactor

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (1)

Considering the low conversion and long reaction time in scaling up reaction in batch reactor, the organocatalyzed epoxidation reaction of styrene was......

High-throughput preparation of uniform tiny droplets in multiple capillaries embedded stepwise microchannels

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (1)

Microfluidic technologies are reliable methods to obtain uniform and tiny droplets, but their application is limited by the capacity of single microch......

Kinetics determination of fast exothermic reactions with infrared thermography in a microreactor

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (1)

In this paper, a microsystem integrated with infrared thermography is developed to measure the kinetics of fast exothermic reactions. The hydrolysis o......

Synthesis of 5-fluoro-2-nitrobenzotrifluoride in a continuous-flow millireactor with a safe and efficient protocol

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (1)

A synthesis process of 5-fluoro-2-nitrobenzotrifluoride was achieved in a continuous-flow millireactor system through the nitration of 3-fluorobenzotr......

Dinitration of o-toluic acid in continuous-flow: process optimization and kinetic study

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (2)

Two types of expeditious and highly efficient continuous-flow processes for the dinitration of o-toluic acid were described. The o-toluic acid was din......

A facile and practical Amination of 4-Fluoronitrobenzene in continuous flow

期刊: JOURNAL OF FLOW CHEMISTRY, 2020; 10 (2)

A highly efficient protocol for the amination of 4-fluoronitrobenzene by using methylamine aqueous solution as the amination reagent was developed. Th......

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