期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Despite The Central Dogma states the destiny of gene as `DNA makes RNA and RNA makes protein', the nucleic acids not only store and transmit genetic i......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Accumulating evidence has shown that microRNAs (miRNAs) play crucial roles in different biological processes, and their mutations and dysregulations h......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
As an important reversible lipid modification, S-palmitoylation mainly occurs at specific cysteine residues in proteins, participates in regulating va......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Inferring how gene expression in a cell is influenced by cellular microenvironment is of great importance yet challenging. In this study, we present a......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
The development of deep sequencing technologies has led to the discovery of novel transcripts. Many in silico methods have been developed to assess th......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Discovering driver pathways is an essential step to uncover the molecular mechanism underlying cancer and to explore precise treatments for cancer pat......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
The novel coronavirus (2019-nCoV) has recently caused a large-scale outbreak of viral pneumonia both in China and worldwide. In this study, we obtaine......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
In this paper, we present a toolset and related resources for rapid identification of viruses and microorganisms from short-read or long-read sequenci......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Drug repositioning can drastically decrease the cost and duration taken by traditional drug research and development while avoiding the occurrence of ......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanical drug ce......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (1)
Emerging evidence shows that microRNAs (miRNAs) play a critical role in diverse fundamental and important biological processes associated with human d......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Identification of new drug-target interactions (DTIs) is an important but a time-consuming and costly step in drug discovery. In recent years, to miti......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Motivation: The emergence of abundant biological networks, which benefit from the development of advanced high-throughput techniques, contributes to d......
期刊： BRIEFINGS IN BIOINFORMATICS, 2021; 22 (2)
Type III secretion systems (T3SS) can be found in many pathogenic bacteria, such as Dysentery bacillus, Salmonella typhimurium, Vibrio cholera and pat......
