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IL-6 modulation for COVID-19: the right patients at the right time?

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (4)

The ongoing pandemic caused by the novel coronavirus SARS-CoV-2 has disrupted the global economy and strained healthcare systems to their limits. Afte......

Cystathionine beta-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8)

Background Hepatocellular carcinoma (HCC) is characterized by inflammation and immunopathogenesis. Accumulating evidence has shown that the cystathion......

WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7)

Background Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor cells and cytotoxic T lymphocytes tumor infiltration in the tumor mi......

B7 score and T cell infiltration stratify immune status in prostate cancer

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8)

Background Although immune checkpoint inhibitors (ICIs), especially programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis bloc......

Metabolic features of cancer cells impact immunosurveillance

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (6)

Background Tumors rewire their metabolism to achieve robust anabolism and resistance against therapeutic interventions like cisplatin treatment. For e......

Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8)

Background Cancer vaccines are a promising strategy for cancer immunotherapy. Cancer vaccines elicits a specific cytotoxic immune response to tumor an......

First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7)

Background Death receptor 5 (DR5) is a promising therapeutic target for cancer therapy. However, many clinical trials of DR5 agonists failed to show s......

Novel anti-4-1BBxPD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7)

Background Stimulation of 4-1BB with agonistic antibodies is a promising strategy for improving the therapeutic efficacy of immune checkpoint inhibito......

Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (4)

Background High-grade gliomas are rapidly progressing tumors of the central nervous system, and are associated with poor prognosis and highly immunosu......

Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7)

Background Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pu......

Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (6)

Background The discovery of checkpoint inhibitors towards cytotoxic T-lymphocyte protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) has bee......

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8)

Background The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mec......

Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (5)

Background Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic land......

Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity

期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (4)

Background In the tumor microenvironment, tumor cells are able to suppress antitumor immunity by competing for essential nutrients, including amino ac......

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