期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021; 22 (8)
Bacteriophage anti-CRISPR proteins evolved to counter CRISPR-Cas-mediated immunity in prokaryotes. Recent structural studies have provided novel insig......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (12)
Sheng-Cai Lin discusses discoveries implicating glycolytic enzyme, aldolase, in glucose sensing.
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (3)
Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several 'rejuvenating' ......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (4)
Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease b......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (8)
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in thei......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (6)
Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (12)
The discovery of the CRISPR-Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (10)
Building a research group in China (when you have not mastered the language) means you face the same problems as elsewhere, with an extra bit of confu......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (11)
The prokaryote-derived CRISPR-Cas genome editing technology has altered plant molecular biology beyond all expectations. Characterized by robustness a......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2019; 20 (9)
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically packaged inside the nucleus. This complex genome organizat......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (5)
Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing ......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (12)
In 1868, Charles Darwin published his Pangenesis theory, which proposed a mechanism for the flow of hereditary information between cells and generatio......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (7)
Few cell signals match the impact of the transforming growth factor-beta (TGF beta) family in metazoan biology. TGF beta cytokines regulate cell fate ......
期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (8)
DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylatio......