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Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (2)

The Food and Drug Administration (FDA) has recently authorized the two messenger RNA (mRNA) vaccines BNT162b2 and mRNA-1273 for emergency use against ......

In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world a......

Pathogenic Factors Identification of Brain Imaging and Gene in Late Mild Cognitive Impairment

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

Mild cognitive impairment (MCI) is a dangerous signal of severe cognitive decline. It can be separated into two steps: early MCI (EMCI) and late MCI (......

Computational Methods and Online Resources for Identification of piRNA-Related Molecules

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (2)

piRNAs are a class of small non-coding RNA molecules, which interact with the PIWI family and have many important and diverse biological functions. Th......

TUPDB: Target-Unrelated Peptide Data Bank

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

The isolation of target-unrelated peptides (TUPs) through biopanning remains as a major problem of phage display selection experiments. These TUPs do ......

Using Network Distance Analysis to Predict lncRNA-miRNA Interactions

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

LncRNA-miRNA interactions contribute to the regulation of therapeutic targets and diagnostic biomarkers in multifarious human diseases. However, it re......

Adaptive Total-Variation Regularized Low-Rank Representation for Analyzing Single-Cell RNA-seq Data

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

High-throughput sequencing of single-cell gene expression reveals a complex mechanism of individual cell's heterogeneity in a population. An important......

i6mA-VC: A Multi-Classifier Voting Method for the Computational Identification of DNA N6-methyladenine Sites

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (3)

DNA N6-methyladenine (6 mA), as an essential component of epigenetic modification, cannot be neglected in genetic regulation mechanism. The efficient ......

An In Silico Method for Predicting Drug Synergy Based on Multitask Learning

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, ; ()

To make better use of all kinds of knowledge to predict drug synergy, it is crucial to successfully establish a drug synergy prediction model and leve......

Accurately Discriminating COVID-19 from Viral and Bacterial Pneumonia According to CT Images Via Deep Learning

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, ; ()

Computed tomography (CT) is one of the most efficient diagnostic methods for rapid diagnosis of the widespread COVID-19. However, reading CT films bri......

Extracting Biomedical Entity Relations using Biological Interaction Knowledge

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, ; ()

Discovering relations of cross-type biomedical entities is crucial for biology research. A large amount of potential or indirect connected biological ......

Mixed Distribution Models Based on Single-Cell RNA Sequencing Data

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, ; ()

Progress in single-cell RNA sequencing (scRNA-seq) has yielded a lot of valuable data. Analysis of these data can provide a new perspective for studyi......

CEGSO: Boosting Essential Proteins Prediction by Integrating Protein Complex, Gene Expression, Gene Ontology, Subcellular Localization and Orthology Information

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, ; ()

Essential proteins are assumed to be an indispensable element in sustaining normal physiological function and crucial to drug design and disease diagn......

Molecular Identification and Phylogenetic Analysis of the Traditional Chinese Medicinal Plant Kochia scoparia Using ITS2 Barcoding

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (1)

Kochia scoparia has high medicinal and economic value. However, with similar morphological features, adulterants and some closely related species of K......

An Algorithm for Gene Fragment Reconstruction

期刊: INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021; 13 (1)

Gene sequencing technology has been playing an important role in many aspects, such as life science, disease medicine and health medicine, particularl......

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