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HKG: an open genetic variant database of 205 Hong Kong cantonese exomes

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (1)

HKG is the first fully accessible variant database for Hong Kong Cantonese, constructed from 205 novel whole-exome sequencing data. There has long bee......

Nano2NGS-Muta: a framework for converting nanopore sequencing data to NGS-liked sequencing data for hotspot mutation detection

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (2)

Nanopore sequencing, also known as single-molecule real-time sequencing, is a third/fourth generation sequencing technology that enables deciphering s......

SPROUT: spectral sparsification helps restore the spatial structure at single-cell resolution

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (3)

Single-cell RNA sequencing thoroughly quantifies the individual cell transcriptomes but renounces the spatial structure. Conversely, recently emerged ......

Adaptive and powerful microbiome multivariate association analysis via feature selection

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (1)

The important role of human microbiome is being increasingly recognized in health and disease conditions. Since microbiome data is typically high dime......

Mining bacterial NGS data vastly expands the complete genomes of temperate phages

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (3)

Temperate phages (active prophages induced from bacteria) help control pathogenicity, modulate community structure, and maintain gut homeostasis. Comp......

Mapping separase-mediated cleavage in situ

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (4)

Separase is a protease that performs critical functions in the maintenance of genetic homeostasis. Among them, the cleavage of the meiotic cohesin dur......

AsgeneDB: a curated orthology arsenic metabolism gene database and computational tool for metagenome annotation

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (4)

Arsenic (As) is the most ubiquitous toxic metalloid in nature. Microbe-mediated As metabolism plays an important role in global As biogeochemical proc......

A comparison on predicting functional impact of genomic variants

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (1)

Single-nucleotide polymorphism (SNPs) may cause the diverse functional impact on RNA or protein changing genotype and phenotype, which may lead to com......

Inferring structural and dynamical properties of gene networks from data with deep learning

期刊: NAR GENOMICS AND BIOINFORMATICS, 2022; 4 (3)

The reconstruction of gene regulatory networks (GRNs) from data is vital in systems biology. Although different approaches have been proposed to infer......

EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases

期刊: NAR GENOMICS AND BIOINFORMATICS, 2021; 3 (2)

Eye diseases are remarkably common and encompass a large and diverse range of morbidities that affect different components of the visual system and vi......

FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks

期刊: NAR GENOMICS AND BIOINFORMATICS, 2021; 3 (2)

Annotating the functions of gene products is a mainstay in biology. A variety of databases have been established to record functional knowledge at the......

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