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A Gene Rank Based Approach for Single Cell Similarity Assessment and Clustering

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

Single-cell RNA sequencing (scRNA-seq) technology provides quantitative gene expression profiles at single-cell resolution. As a result, researchers h......

Improve the Resolution and Parallel Performance of the Three-Dimensional Refine Algorithm in RELION Using CUDA and MPI

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

In cryo-electron microscopy, RELION is a powerful tool for high-resolution reconstruction. Due to the complicated imaging procedure and the heterogene......

AFSBN: A Method of Artificial Fish Swarm Optimizing Bayesian Network for Epistasis Detection

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (4)

How to mine the interaction between SNPs (namely epistasis) efficiently and accurately must be considered when to tackle the complexity of underlying ......

A Convolutional Neural Network System to Discriminate Drug-Target Interactions

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (4)

Biological targets are most commonly proteins such as enzymes, ion channels, and receptors. They are anything within a living organism to bind with so......

Predicting in-vitro Transcription Factor Binding Sites Using DNA Sequence plus Shape

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

Discovery of transcription factor binding sites (TFBSs) is essential for understanding the underlying binding mechanisms and cellular functions. Recen......

LDAH2V: Exploring Meta-Paths Across Multiple Networks for lncRNA-Disease Association Prediction

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (4)

Accumulating evidence has demonstrated dysfunctions of long non-coding RNAs (lncRNAs) are involved in various complex human diseases. However, even to......

A Cascade of 2.5D CNN and Bidirectional CLSTM Network for Mitotic Cell Detection in 4D Microscopy Image

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

Mitosis detection is one of the challenging steps in biomedical imaging research, which can be used to observe the cell behavior. Most of the already ......

Scalable De Novo Genome Assembly Using a Pregel-Like Graph-Parallel System

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

De novo genome assembly is the process of stitching short DNA sequences to generate longer DNA sequences, without using any reference sequence for ali......

LWPCMF: Logistic Weighted Profile-Based Collaborative Matrix Factorization for Predicting MiRNA-Disease Associations

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (3)

As is known to all, constructing experiments to predict unknown miRNA-disease association is time-consuming, laborious and costly. Accordingly, new pr......

Identify Consistent Cross-Modality Imaging Genetic Patterns via Discriminant Sparse Canonical Correlation Analysis

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (4)

Sparse canonical correlation analysis (SCCA) is a bi-multivariate technique used in imaging genetics to identify complex multi-SNP-multi-QT associatio......

Predicting the Antigenic Relationship of Foot-and-Mouth Disease Virus for Vaccine Selection Through a Computational Model

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (2)

Foot-and-mouth disease virus (FMDV) is an antigenic-variable RNA virus that is responsible for the recurrence of foot-and-mouth disease in livestock a......

Deletion Detection Method Using the Distribution of Insert Size and a Precise Alignment Strategy

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (3)

Homozygous and heterozygous deletions commonly exist in the human genome. For current structural variation detection tools, it is significant to deter......

Data-Enabled Digestive Medicine: A New Big Data Analytics Platform

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (3)

This paper presents a big data analystics platform for clinical research and practice in the Gastroenterology Department of Xiangya Hospital at Centra......

Human Gait Recognition Based on Self-Adaptive Hidden Markov Model

期刊: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021; 18 (3)

Human gait recognition has numerous challenges due to view angle changing, human dressing, bag carrying, and pedestrian walking speed, etc. In order t......

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