期刊： DRUG METABOLISM REVIEWS, 2019; 51 (1)
Patulin is a mycotoxin produced by a number of filamentous fungal species. It is a polyketide secondary metabolite which can gravely cause human healt......
期刊： DRUG METABOLISM REVIEWS, 2019; 51 (2)
Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (2)
Traditional Chinese medicines (TCMs) have a long history for safely treating human diseases. Unlike western medicine, TCMs usually contain multiple co......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (2)
Drug metabolism plays vital roles in the absorption and pharmacological activity of poorly soluble natural medicines. It is important to choose suitab......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (3)
There will be 642 million people worldwide by 2040 suffering from diabetes mellitus. Long-term multidrug therapy aims to achieve normal glycemia and m......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (3)
Gut microbiota, one of the determinants of pharmacokinetics, has long been underestimated. It is now generally accepted that the gut microbiota plays ......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (3)
Flavonoids are a group of phytochemicals widely distributed in plants, fruits, and vegetables that possess numerous bioactivities. After oral administ......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (4)
After administration, drug molecules usually enter target cells to access their intracellular targets. In eukaryotic cells, these targets are often lo......
期刊： DRUG METABOLISM REVIEWS, 2018; 50 (4)
Nuclear receptors (NRs) belong to a family of ligand-dependent transcription factors. The target genes of NRs include many drug metabolizing enzymes a......
期刊： DRUG METABOLISM REVIEWS, 2022; 54 (2)
Interindividual differences in drug response have always existed in clinical treatment. Genes involved in drug absorption, distribution, metabolism, a......
期刊： DRUG METABOLISM REVIEWS, 2022; 54 (1)
UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubi......
期刊： DRUG METABOLISM REVIEWS, 2022; 54 (3)
Deoxynivalenol (DON) and its modified forms, including DON-3-glucoside (DON-3G), pose a major agricultural and food safety issue in the world. Their m......
期刊： DRUG METABOLISM REVIEWS, 2022; 54 (4)
HNF4 alpha and HNF1 alpha are core transcription factors involved in the development and progression of a variety of human diseases and drug metabolis......
期刊： DRUG METABOLISM REVIEWS, 2017; 49 (2)
Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple pharmacological effects, including antimicrobial, antidiab......
期刊： DRUG METABOLISM REVIEWS, 2017; 49 (2)
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is u......
